ArticleScientific reports2019
Hypochlorous-Acid-Generating Electrochemical Scaffold for Treatment of Wound Biofilms.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Hypochlorous acid hygiene solution in patients affected by blepharitis: a prospective randomised study.BMJ open ophthalmology · 2023Trial
- An astragalus polysaccharide-loaded hydrogel dressing enhances diabetic wound healing via dual-mode electrical stimulation.Bioactive materials · 2026Article
- Sculpting Microbial Microenvironments: Spatiotemporal Control via Programmable Electrochemical Gradients.Journal of the American Chemical Society · 2026Review
- Engineering an electroactive bacterial cellulose-carbon nanotube composite membrane againstBiofilm · 2025Article
- The Rising Importance of Antiseptics in Ophthalmology: From Endophthalmitis Prevention to Treatment of Ocular Infections.Ophthalmology and therapy · 2025Review
- Activity of HOCl-generating e-bandage with clinically available hydrogels againstMicrobiology spectrum · 2025Article
- Periprosthetic joint infection after arthroplasty: advances and future prospects.Journal of orthopaedic surgery and research · 2025Review
- Review
- Electrochemical Catheter Hub Operated by a Wearable Micropotentiostat Prevents Acinetobacter baumannii Infection In Vitro.Biotechnology and bioengineering · 2025Article
- Article
- Dual action electrochemical bandage operated by a programmable multimodal wearable potentiostat.Biosensors & bioelectronics · 2025Article
- HOCl-producing electrochemical bandage is active in murine polymicrobial wound infection.Microbiology spectrum · 2024Article
- Evaluation of treatment of methicillin-resistantAntimicrobial agents and chemotherapy · 2024Article
- Evaluation of Treatment of Methicillin-ResistantbioRxiv : the preprint server for biology · 2024Article
- The HOCl dry fog-is it safe for human cells?PloS one · 2024Article
- Hypochlorous Acid for Wound Healing in Diabetic Rats: Effect on MMP-9 and Histology.Clinical, cosmetic and investigational dermatology · 2024Review
- In vitro activity of hypochlorous acid generating electrochemical bandage against monospecies and dual-species bacterial biofilms.Journal of applied microbiology · 2023Article
- 0.01% Hypochlorous Acid Treats Aspergillus fumigatus Keratitis in Rats by Reducing Fungal Load and Inhibiting the Inflammatory Response.Translational vision science & technology · 2023Article
- Hypochlorous acid inactivates oral pathogens and a SARS-CoV-2-surrogate.BMC oral health · 2023Article
- Effect of Hypochlorous Acid on Blepharitis through Ultrasonic Atomization: A Randomized Clinical Trial.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Biofilm formation causes prolonged wound infections due to the dense biofilm structure, differential gene regulation to combat stress, and production of extracellular polymeric substances. Acinetobacter baumannii, Staphylococcus aureus, and Pseudomonas aeruginosa are three difficult-to-treat biofilm-forming bacteria frequently found in wound infections. This work describes a novel wound dressing in the form of an electrochemical scaffold (e-scaffold) that generates controlled, low concentrations of hypochlorous acid (HOCl) suitable for killing biofilm communities without substantially damaging host tissue. Production of HOCl near the e-scaffold surface was verified by measuring its concentration using needle-type microelectrodes. E-scaffolds producing 17, 10 and 7 mM HOCl completely eradicated S. aureus, A. baumannii, and P. aeruginosa biofilms after 3 hours, 2 hours, and 1 hour, respectively. Cytotoxicity and histopathological assessment showed no discernible harm to host tissues when e-scaffolds were applied to explant biofilms. The described strategy may provide a novel antibiotic-free strategy for treating persistent biofilm-associated infections, such as wound infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.