Evidence map›Paper›PMID 30804324›Full record

ArticleNutrition & diabetes2019

Comparison of visceral fat measurement by dual-energy X-ray absorptiometry to computed tomography in HIV and non-HIV.

Lindsay T Fourman, Emma M Kileel, Jane Hubbard, Tara Holmes, Ellen J Anderson, Sara E Looby, Kathleen V Fitch, Meghan N Feldpausch, Martin Torriani, Janet Lo and 2 more

Registry-linked trialOpen access · goldAbstract readComparative Study
In one paragraph

Article in Nutrition & diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05383456 (The Visceral Adiposity Measurement and Observation Study), which is not on this map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05383456 completednot on this mapstarted 2022, after this paper: background citation

The Visceral Adiposity Measurement and Observation Study

TypeobservationalSponsorTheratechnologiesRan2022 to 2023Enrolled196ConditionsHIV, HIV-Infections, HIV-1-infection, HIV I InfectionArmsDiagnostic Test, HIV Anti-retroviral Background Therapy
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Precision or Paradox? AI-Driven Adiposity Imaging in Women With Overweight and Obesity: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Pooled it
  2. Pooled it
  3. Article
  4. Article
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  6. Weight Gain and Antiretroviral Therapy.Infectious disease clinics of North America · 2024
    Review
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  16. Observational
  17. Obesity and Weight Gain in Persons with HIV.Current HIV/AIDS reports · 2020 · on this map
    Review
  18. MRI Based Validation of Abdominal Adipose Tissue Measurements From DXA in Postmenopausal Women.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Lindsay T FourmanProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Emma M KileelProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Jane HubbardTranslational and Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0002-5658-9294
Tara HolmesTranslational and Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA.
Ellen J AndersonTranslational and Clinical Research Center, Massachusetts General Hospital, Boston, MA, USA.
Sara E LoobyProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Kathleen V FitchProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Meghan N FeldpauschProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Martin TorrianiMGH Metabolic Imaging Core, Department of Radiology, Massachusetts General Hospital, Boston, MA, USA.
Janet LoProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Takara L StanleyProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Steven K GrinspoonProgram in Nutritional Metabolism, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA. sgrinspoon@mgh.harvard.edu.
Massachusetts General Hospital · US

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
HARVARD CLINICAL AND TRANSLATIONAL SCIENCE CENTER (UL1)UL1RR025758 · NCRR · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2008 to 2011
$91.4M
ZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI HALL, JANET E · 1985 to 2008
$37.4M
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6M
TESTOSTERONE AND GROWTH HORMONE EFFECTS IN AIDS WASTINGR01DK049302 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI ADLER, GAIL KURR, GRINSPOON, STEVEN K. · 1995 to 2020
$12.2M
Cardiac MR and CT ResearchT32HL076136 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NEILAN, TOMAS G · 2004 to 2019
$4.9M
Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIVR01HL095123 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI GRINSPOON, STEVEN K. · 2009 to 2013
$4.6M
Physiologic Growth Hormone Effects in HIV LipodystrophyR01DK063639 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI GRINSPOON, STEVEN K. · 2003 to 2012
$4.3M
Metabolic Effects of Augmenting Pulsatile Growth Hormone Secretion in HIV-InfectiK23DK089910 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI STANLEY, TAKARA LEAH · 2010 to 2014
$795k
Atherosclerosis and Inflammation in HIV DiseaseK23HL092792 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LO, JANET · 2008 to 2012
$705k
Metabolic and Psychosocial Changes Associated with Menopause among Women with HIVK23NR011833 · NINR · MASSACHUSETTS GENERAL HOSPITAL · PI LOOBY, SARA ELIZABETH DOLAN · 2010 to 2012
$403k
NCATS NIH HHS UL1 TR002541NCRR NIH HHS M01 RR001066NCRR NIH HHS UL1 RR025758NHLBI NIH HHS F32 HL088991NHLBI NIH HHS K23 HL092792NHLBI NIH HHS R01 HL095123NHLBI NIH HHS T32 HL076136NIAID NIH HHS P30 AI060354NIDDK NIH HHS K23 DK089910NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK049302NIDDK NIH HHS R01 DK063639NINR NIH HHS K23 NR011833
6 · The paper itself

Abstract

BACKGROUND/

objectivesIndividuals with HIV are susceptible to visceral fat accumulation, which confers an increased risk of cardiometabolic disease. Advanced software to ascertain visceral fat content from dual-energy X-ray absorptiometry (DXA) has not been validated among this population. We sought to compare DXA with computed tomography (CT) in the measurement of visceral fat cross-sectional area (VAT) in HIV and non-HIV using Bland-Altman analyses. SUBJECTS/

methodsData were combined from five previously conducted studies of individuals with HIV (n = 313) and controls without HIV (n = 144) in which paired DXA and CT scans were available. In cross-sectional analyses, DXA-VAT was compared with CT-VAT among participants with and without HIV. In longitudinal analyses, changes in VAT over time were compared between DXA and CT among participants with and without HIV receiving no intervention over 12 months and among individuals with HIV receiving tesamorelin-a medication known to reduce VAT-over 6 months.

resultsIn HIV, DXA underestimated VAT compared with CT among individuals with increased visceral adiposity. The measurement bias was -9 ± 47 cm

conclusionsDXA underestimated VAT relative to CT in men with and without HIV, who had increased visceral adiposity. DXA also underestimated changes in VAT over time in men and women, irrespective of HIV status. DXA-VAT should be used with caution among both HIV and non-HIV-infected populations.

Indexed as

Absorptiometry, PhotonTomography, X-Ray ComputedAdiposityAdultBody CompositionBody Mass IndexFemaleHIV InfectionsHumansIntra-Abdominal FatMaleMiddle AgedSex FactorsWaist Circumference

Identifiers

PMID30804324
PMCPMC6389911
OpenAlexW2916766670

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.