Evidence map›Paper›PMID 30804209›Full record

ArticleThe Journal of biological chemistry2019

Cellular cholesterol abundance regulates potassium accumulation within endosomes and is an important determinant in bunyavirus entry.

Frank W Charlton, Samantha Hover, Jack Fuller, Roger Hewson, Juan Fontana, John N Barr, Jamel Mankouri

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Frank W CharltonFrom the School of Molecular and Cellular Biology and.
Samantha HoverFrom the School of Molecular and Cellular Biology and.
Jack Fullerthe National Infection Service, Public Health England, Porton Down, Salisbury SP4 0JG, United Kingdom.
Roger Hewsonthe National Infection Service, Public Health England, Porton Down, Salisbury SP4 0JG, United Kingdom.
Juan FontanaFrom the School of Molecular and Cellular Biology and.
John N BarrFrom the School of Molecular and Cellular Biology and j.n.barr@leeds.ac.uk.
Jamel MankouriFrom the School of Molecular and Cellular Biology and j.mankouri@leeds.ac.uk.
University of Leeds · GBPublic Health England · GB

Funding

Wellcome TrustWellcome Trust 090932/Z/09/Z
6 · The paper itself

Abstract

The Bunyavirales order of segmented negative-sense RNA viruses includes more than 500 isolates that infect insects, animals, and plants and are often associated with severe and fatal disease in humans. To multiply and cause disease, bunyaviruses must translocate their genomes from outside the cell into the cytosol, achieved by transit through the endocytic network. We have previously shown that the model bunyaviruses Bunyamwera virus (BUNV) and Hazara virus (HAZV) exploit the changing potassium concentration ([K

Indexed as

Virus InternalizationCell Line, TumorCholesterolEndocytosisEndosomesHumansIon TransportOrthobunyavirusPotassiumVirionCholesterolPotassiumcholesterolendosomepotassium channelpotassium transportvirologyvirus entry

Identifiers

PMID30804209
PMCPMC6509484
OpenAlexW2915995639

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.