ArticleProceedings of the National Academy of Sciences of the United States of America2019
Central role of G protein Gαi2 and Gαi2
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 75 citations in OpenAlex.
- Androstadienone modulates human aggression in a sex-dependent manner.Social cognitive and affective neuroscience · 2023Trial
- Kirrel3 homophilic adhesion function is required for male-directed aggression and vomeronasal acuity to urine chemosignals.Frontiers in cellular neuroscience · 2026Article
- Leveraging artificial intelligence in bioacoustics for animal health monitoring and early diagnosis in veterinary medicine.Frontiers in veterinary science · 2026Review
- Killing behaviors in rodents: from predation to infanticide.Frontiers in behavioral neuroscience · 2026Review
- Article
- Cystic fibrosis alters the structure of the olfactory epithelium and the expression of olfactory receptors affecting odor perception.Science advances · 2025Article
- Behavioral Assays in the Study of Olfaction.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Article
- Article
- Effect of the social environment on olfaction and social skills in wild-type and a mouse model of autism.Translational psychiatry · 2024Article
- Molecular, Cellular, and Developmental Organization of the Mouse Vomeronasal organ at Single Cell Resolution.bioRxiv : the preprint server for biology · 2024Article
- Sexual discrimination and attraction through scents in the water vole, Arvicola terrestris.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Following the p63/Keratin5 basal cells in the sensory and non-sensory epithelia of the vomeronasal organ.Genesis (New York, N.Y. : 2000) · 2024Article
- Neural basis for pheromone signal transduction in mice.Frontiers in neural circuits · 2024Review
- A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.Science advances · 2023Article
- Sensing and avoiding sick conspecifics requires Gαi2BMC biology · 2023Article
- Does the Environmental Air Impact the Condition of the Vomeronasal Organ? A Mouse Model for Intensive Farming.Animals : an open access journal from MDPI · 2023Article
- Optical Activation of Photoswitchable TRPC Ligands in the Mammalian Olfactory System Using Laser Scanning Confocal Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Presynaptic GABAFrontiers in cellular neuroscience · 2023Article
- Behavioral evidence of the functional interaction between the main and accessory olfactory system suggests a large olfactory system with a high plastic capability.Frontiers in neuroanatomy · 2023Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 4 countries.
Funding
Abstract
Aggression is controlled by the olfactory system in many animal species. In male mice, territorial and infant-directed aggression are tightly regulated by the vomeronasal organ (VNO), but how diverse subsets of sensory neurons convey pheromonal information to limbic centers is not yet known. Here, we employ genetic strategies to show that mouse vomeronasal sensory neurons expressing the G protein subunit Gαi2 regulate male-male and infant-directed aggression through distinct circuit mechanisms. Conditional ablation of Gαi2 enhances male-male aggression and increases neural activity in the medial amygdala (MeA), bed nucleus of the stria terminalis, and lateral septum. By contrast, conditional Gαi2 ablation causes reduced infant-directed aggression and decreased activity in MeA neurons during male-infant interactions. Strikingly, these mice also display enhanced parental behavior and elevated neural activity in the medial preoptic area, whereas sexual behavior remains normal. These results identify Gαi2 as the primary G protein α-subunit mediating the detection of volatile chemosignals in the apical layer of the VNO, and they show that Gαi2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.