Evidence map›Paper›PMID 30804201›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Recovery from tachyphylaxis of TRPV1 coincides with recycling to the surface membrane.

Quan Tian, Juan Hu, Chang Xie, Kaidi Mei, Cuong Pham, Xiaoyi Mo, Régine Hepp, Sylvia Soares, Fatiha Nothias, Yuanyuan Wang and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Vagal nerve TRPV3 regulates sedative-mediated appeasement.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. A journey from molecule to physiology andFrontiers in pharmacology · 2023
    Review
  13. Progress in the Structural Basis of thermoTRP Channel Polymodal Gating.International journal of molecular sciences · 2023
    Review
  14. Inhibitions and Down-Regulation of Motor Protein Eg5 Expression in Primary Sensory Neurons Reveal a Novel Therapeutic Target for Pathological Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Quan TianHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Juan HuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Chang XieHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Kaidi MeiHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Cuong PhamSorbonne Université, Institut de Biologie de Paris-Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, 75005 Paris, France.
Xiaoyi MoHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Régine HeppSorbonne Université, Institut de Biologie de Paris-Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, 75005 Paris, France.
Sylvia SoaresSorbonne Université, Institut de Biologie de Paris-Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, 75005 Paris, France.
Fatiha NothiasSorbonne Université, Institut de Biologie de Paris-Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, 75005 Paris, France.
Yuanyuan WangHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Qiang LiuHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Fen CaiHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Bo ZhongHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China.
Dongdong LiSorbonne Université, Institut de Biologie de Paris-Seine, Neuroscience Paris Seine, CNRS UMR8246, INSERM U1130, 75005 Paris, France dongdong.li@inserm.fr jyao@whu.edu.cn.
Jing YaoHubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, 430072 Hubei, China; dongdong.li@inserm.fr jyao@whu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transient receptor potential vanilloid-1 (TRPV1) ion channel is essential for sensation of thermal and chemical pain. TRPV1 activation is accompanied by Ca

Indexed as

EndocytosisTachyphylaxisAnimalsCalcium SignalingCell MembraneExocytosisHEK293 CellsHumansLightProtein TransportRatsSynaptotagminsTRPV Cation ChannelsSynaptotagminsTRPV Cation ChannelscalciumdesensitizationpainsynaptotagminTRP channel

Identifiers

PMID30804201
PMCPMC6421460

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.