Evidence map›Paper›PMID 30804148›Full record

ArticleIn vivo (Athens, Greece)

Radiation-induced Oral Mucositis in Brazilian Patients: Prevalence and Associated Factors.

Igor Figueiredo Pereira, Ramon Targino Firmino, Henrique Cortes Meira, Belmiro Cavalcanti DO Egito Vasconcelos, Vladimir Reimar Augusto DE Souza Noronha, Vagner Rodrigues Santos

Open access · diamondAbstract read
In one paragraph

Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. The prevalence of oral mucositis after radiotherapy in patients with Head and Neck Cancer and its associated factors: a meta-analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Investigating the effect of Aloe vera on the prevention and treatment of radiotherapy-induced oral mucositis in patients with head-and-neck cancer.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2024
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Igor Figueiredo PereiraDepartment of Prosthodontics and Bucco-Facial Surgery, School of Dentistry, University of Pernambuco, Camaragibe, Brazil figueiredo.ctbmf@gmail.com.
Ramon Targino FirminoDepartment of Pediatric Dentistry and Orthodontics, School of Dentistry, Federal University of Minas Gerais, Pampulha Belo Horizonte, Brazil.
Henrique Cortes MeiraDepartment of Clinical, Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais, Pampulha Belo Horizonte, Brazil.
Belmiro Cavalcanti DO Egito VasconcelosDepartment of Prosthodontics and Bucco-Facial Surgery, School of Dentistry, University of Pernambuco, Camaragibe, Brazil.
Vladimir Reimar Augusto DE Souza NoronhaDepartment of Surgery, University Center of Newton Paiva, Belo Horizonte, Brazil.
Vagner Rodrigues SantosDepartment of Clinical, Pathology and Surgery, School of Dentistry, Federal University of Minas Gerais, Pampulha Belo Horizonte, Brazil.
Universidade Federal de Minas Gerais · BRUniversidade de Pernambuco · BRCentro Universitário Newton Paiva · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: To determine the prevalence of radiation-induced oral mucositis (OM) and associated factors. PATIENTS AND

methodsA cross-sectional retrospective study was performed at a reference dental care center. The medical records of patients submitted to radiotherapy for the treatment of head and neck cancer were used to collect clinical and demographic variables. The data were submitted to descriptive analysis and multivariate Poisson regression with robust variance [p<0.05; 95% confidence intervaI (CI)].

resultsFour hundred and thirteen patients were analyzed. The mean age was 55±14 years. The prevalence of OM in the overall sample was 41.9% and was higher among males (78.2%). The following variables were significantly associated with the outcome: radiation dose [prevalence ratio (PR)= 1.04; 95% CI=1.02-1.06]; concomitant chemotherapy (PR=1.48, 95% CI=1.05-2.08); oral candidiasis (PR=1.97, 95% CI=1.44-2.68); and osteoradionecrosis (PR=1.51, 95% CI=1.10-2.06).

conclusionRadiation-induced OM was associated with radiation dose, concomitant chemotherapy, oral candidiasis and osteoradionecrosis. The rate of OM underscores the importance of adequate oral care prior to treatment for head and neck cancer.

Indexed as

BrazilDental CareFemaleHead and Neck NeoplasmsHumansMaleMiddle AgedRadiation InjuriesStomatitischemotherapyepidemiologyhead and neck canceroral mucositisRadiotherapy

Identifiers

PMID30804148
PMCPMC6506295
OpenAlexW2915882923

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.