Evidence map›Paper›PMID 30804095›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.

Yalun Tan, Sarthak M Singhal, Scott W Harden, Karlena M Cahill, Dan-Tam M Nguyen, Luis M Colon-Perez, Todd J Sahagian, Jeffrey S Thinschmidt, Annette D de Kloet, Marcelo Febo and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 118 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. The Anterior BNST Is Required for Novelty-Driven Social Interaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  8. Impact of early social isolation on social circuits and behavior: relevance to schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Perineuronal Nets on CA2 Pyramidal Cells and Parvalbumin-Expressing Cells Differentially Regulate Hippocampal-Dependent Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Yalun TanDepartment of Pharmacodynamics, College of Pharmacy.
Sarthak M SinghalDepartment of Pharmacodynamics, College of Pharmacy.
Scott W HardenDepartment of Pharmacodynamics, College of Pharmacy.ORCID 0000-0002-0757-1979
Karlena M CahillDepartment of Pharmacodynamics, College of Pharmacy.
Dan-Tam M NguyenDepartment of Pharmacodynamics, College of Pharmacy.
Luis M Colon-PerezDepartment of Psychiatry, College of Medicine.ORCID 0000-0001-8918-2418
Todd J SahagianDepartment of Pharmacodynamics, College of Pharmacy.
Jeffrey S ThinschmidtDepartment of Pharmacodynamics, College of Pharmacy.
Annette D de KloetDepartment of Physiology and Functional Genomics, College of Medicine, and.ORCID 0000-0002-7213-6957
Marcelo FeboDepartment of Psychiatry, College of Medicine.ORCID 0000-0001-8981-4163
Charles J FrazierDepartment of Pharmacodynamics, College of Pharmacy, cjfraz@ufl.edu ekrause@cop.ufl.edu.ORCID 0000-0003-3550-4789
Eric G KrauseDepartment of Pharmacodynamics, College of Pharmacy, cjfraz@ufl.edu ekrause@cop.ufl.edu.
University of Florida · USInstitute for Clinical Pharmacodynamics (United States) · US

Funding

Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertensionR01HL145028 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2019 to 2023
$1.9M
Central Mechanisms Underlying the Stress Dampening Effects of Acute HypernatremiaR01HL122494 · NHLBI · UNIVERSITY OF FLORIDA · PI KRAUSE, ERIC GERALD · 2015 to 2019
$1.9M
Novel Aspects of Central Oxytocin Signaling Relevant to Mood/Anxiety DisordersR01MH104641 · NIMH · UNIVERSITY OF FLORIDA · PI FRAZIER, CHARLES J · 2015 to 2019
$1.9M
Novel role of central AT2R in blood pressure regulationR00HL125805 · NHLBI · UNIVERSITY OF FLORIDA · PI DE KLOET, ANNETTE DIANE · 2016 to 2018
$746k
NHLBI NIH HHS R00 HL125805NHLBI NIH HHS R01 HL122494NHLBI NIH HHS R01 HL145028NIMH NIH HHS R01 MH104641
6 · The paper itself

Abstract

Social recognition, the ability to recognize individuals that were previously encountered, requires complex integration of sensory inputs with previous experience. Here, we use a variety of approaches to discern how oxytocin-sensitive neurons in the PFC exert descending control over a circuit mediating social recognition in mice. Using male mice with Cre-recombinase directed to the oxytocin receptor gene (

Indexed as

Social BehaviorAnimalsGlutamic AcidMaleMiceMice, TransgenicNeuronsOptogeneticsPrefrontal CortexReceptors, OxytocinRecognition, PsychologyGlutamic AcidReceptors, Oxytocinanxietyautismbasolateral amygdalabed nucleus of the stria terminalisnucleus accumbenssocial novelty

Identifiers

PMID30804095
PMCPMC6788819
OpenAlexW2917785150

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.