ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
The Firing Rate Speed Code of Entorhinal Speed Cells Differs across Behaviorally Relevant Time Scales and Does Not Depend on Medial Septum Inputs.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Article
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Grid maps are disrupted after large-scale arena expansion and recover with experience.Nature communications · 2026Article
- Boundary Vector Cells Encode a Future-Biased Spectrum of Positions in the Rat.bioRxiv : the preprint server for biology · 2026Article
- Cholinergic Dynamics in the Septo-hippocampal System Provide Phasic Multiplexed Signals for Spatial Novelty and Correlate with Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Spatial periodicity in grid cell firing is explained by a neural sequence code of 2-D trajectories.eLife · 2025Article
- Medial septal theta stimulation enhances spatial working memory performance in rats.Learning & memory (Cold Spring Harbor, N.Y.) · 2025Article
- Impairment of theta oscillations in the hippocampal CA1 region may mediate age-dependent movement alternations in the 5xFAD mouse model of Alzheimer's disease.Scientific reports · 2025Article
- The influence of emotion on temporal context models.Cognition & emotion · 2025Review
- Cholinergic dynamics in the septo-hippocampal system provide phasic multiplexed signals for spatial novelty and correlate with behavioral states.bioRxiv : the preprint server for biology · 2025Article
- Development of the SPEAR Model: Separate Phases of Encoding and Retrieval Are Necessary for Storing Multiple Overlapping Associative Memories.Hippocampus · 2025Review
- A Continuous Attractor Model with Realistic Neural and Synaptic Properties Quantitatively Reproduces Grid Cell Physiology.International journal of molecular sciences · 2024Article
- A Continuous Attractor Model with Realistic Neural and Synaptic Properties Quantitatively Reproduces Grid Cell Physiology.bioRxiv : the preprint server for biology · 2024Article
- Septo-hippocampal dynamics and the encoding of space and time.Trends in neurosciences · 2023Review
- Cortical Integration of Vestibular and Visual Cues for Navigation, Visual Processing, and Perception.Annual review of neuroscience · 2023Review
- Gated transformations from egocentric to allocentric reference frames involving retrosplenial cortex, entorhinal cortex, and hippocampus.Hippocampus · 2023Review
- Article
- Microcircuits for spatial coding in the medial entorhinal cortex.Physiological reviews · 2022Review
- Adaptive integration of self-motion and goals in posterior parietal cortex.Cell reports · 2022Article
- Functional network topography of the medial entorhinal cortex.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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Authors and funding
5 authors.
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Abstract
The firing rate of speed cells, a dedicated subpopulation of neurons in the medial entorhinal cortex (MEC), is correlated with running speed. This correlation has been interpreted as a speed code used in various computational models for path integration. These models consider firing rate to be linearly tuned by running speed in real-time. However, estimation of firing rates requires integration of spiking events over time, setting constraints on the temporal accuracy of the proposed speed code. We therefore tested whether the proposed speed code by firing rate is accurate at short time scales using data obtained from open-field recordings in male rats and mice. We applied a novel filtering approach differentiating between speed codes at multiple time scales ranging from deciseconds to minutes. In addition, we determined the optimal integration time window for firing-rate estimation using a general likelihood framework and calculated the integration time window that maximizes the correlation between firing rate and running speed. Data show that these time windows are on the order of seconds, setting constraints on real-time speed coding by firing rate. We further show that optogenetic inhibition of either cholinergic, GABAergic, or glutamatergic neurons in the medial septum/diagonal band of Broca does not affect modulation of firing rates by running speed at each time scale tested. These results are relevant for models of path integration and for our understanding of how behavioral activity states may modulate firing rates and likely information processing in the MEC.
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