Evidence map›Paper›PMID 30804090›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

Plexina2 and CRMP2 Signaling Complex Is Activated by Nogo-A-Liganded Ngr1 to Restrict Corticospinal Axon Sprouting after Trauma.

Yuichi Sekine, Percy T Algarate, William B J Cafferty, Stephen M Strittmatter

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
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  5. Review
  6. The Nogo-66 Receptors NgR1 and NgR3 Are Required for Commissural Axon Pathfinding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  7. Article
  8. Article
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  10. Article
  11. Review
  12. Article
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  15. Article
  16. Review
  17. Pericytes: Problems and Promises for CNS Repair.Frontiers in cellular neuroscience · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yuichi SekineCellular Neuroscience, Neurodegeneration, and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536.ORCID 0000-0002-2861-603X
Percy T AlgarateDepartments of Neurology, and.
William B J CaffertyDepartments of Neurology, and.ORCID 0000-0001-6263-2167
Stephen M StrittmatterCellular Neuroscience, Neurodegeneration, and Repair Program, Yale University School of Medicine, New Haven, Connecticut 06536, stephen.strittmatter@yale.edu.ORCID 0000-0001-8188-3092
Yale University · US

Funding

Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
Evaluation of Novel Targets for Retinal Ganglion Cell Axon RegenerationU01EY027256 · NEI · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2016 to 2018
$2.0M
NEI NIH HHS U01 EY027256NINDS NIH HHS R35 NS097283
6 · The paper itself

Abstract

After brain or spinal cord trauma, interaction of Nogo-A with neuronal NgR1 limits regenerative axonal sprouting and functional recovery. Cellular signaling by lipid-anchored NgR1 requires a coreceptor but the relevant partner

Indexed as

AnimalsAxonsChlorocebus aethiopsCOS CellsIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutMotor ActivityNerve RegenerationNerve Tissue ProteinsNeuronsNogo ProteinsNogo Receptor 1Pyramidal TractsReceptors, Cell SurfaceRecovery of Functioncollapsin response mediator protein-2Intercellular Signaling Peptides and ProteinsNerve Tissue ProteinsNogo ProteinsNogo Receptor 1Plxna2 protein, mouseReceptors, Cell SurfacecorticospinalCRMPNogo receptorplasticityPlexinpyramidotomy

Identifiers

PMID30804090
PMCPMC6788813
OpenAlexW2916037138

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.