Evidence map›Paper›PMID 30804041›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2019

Respiratory Enterovirus (like Parainfluenza Virus) Can Cause Chronic Lung Disease if Protection by Airway Epithelial STAT1 Is Lost.

Yong Zhang, Dailing Mao, Shamus P Keeler, Xinyu Wang, Kangyun Wu, Benjamin J Gerovac, Laurie L Shornick, Eugene V Agapov, Michael J Holtzman

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. The post-viral GPNMBmedRxiv : the preprint server for health sciences · 2024
    Article
  5. Article
  6. Article
  7. Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease.European respiratory review : an official journal of the European Respiratory Society · 2024
    Article
  8. A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. An alternative mechanism for skeletal muscle dysfunction in long-term post-viral lung disease.American journal of physiology. Lung cellular and molecular physiology · 2023
    Article
  13. Article
  14. Article
  15. Article
  16. Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model.American journal of physiology. Lung cellular and molecular physiology · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Yong ZhangPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-1620-2646
Dailing MaoPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Shamus P KeelerPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-1301-0852
Xinyu WangPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Kangyun WuPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-8093-094X
Benjamin J GerovacPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0003-2641-5856
Laurie L ShornickPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0001-6652-1878
Eugene V AgapovPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110.
Michael J HoltzmanPulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110 mjholtzman@wustl.edu.
Washington University in St. Louis · US

Funding

The role of CARDS toxin in genesis and exacerbation of allergic inflammationU19AI070412 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BASEMAN, JOEL BARRY · 2006 to 2015
$19.7M
Preclinical Development of an Anti-Mucus DrugUH3HL123429 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2016 to 2018
$4.7M
PARP9-DTX3L Control Of Viral Infection and Airway DiseaseR01AI130591 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2017 to 2021
$3.0M
IL-33 AND EXCESS MUCUS PRODUCTIONR01HL121791 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2014 to 2017
$1.9M
INTERFERON SIGNAL ENHANCERS AS ANTIVIRAL THERAPEUTICSR01AI111605 · NIAID · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2014 to 2017
$1.8M
TREM2 AND AIRWAY DISEASER01HL120153 · NHLBI · WASHINGTON UNIVERSITY · PI HOLTZMAN, MICHAEL J · 2016 to 2018
$1.3M
NHLBI NIH HHS R01 HL120153NHLBI NIH HHS R01 HL121791NHLBI NIH HHS UH3 HL123429NIAID NIH HHS R01 AI111605NIAID NIH HHS R01 AI130591NIAID NIH HHS U19 AI070412
6 · The paper itself

Abstract

Epithelial barrier cells are proposed to be critical for host defense, and airway epithelial cell capacity for IFN signal transduction is presumed to protect against respiratory viral infection. However, it has been difficult to fully test these concepts given the absence of tools to analyze IFN signaling specific to airway epithelial cells in vivo. To address these issues, we generated a new line of transgenic mice with

Indexed as

AnimalsChronic DiseaseEpithelial CellsLung DiseasesMiceMice, KnockoutRespirovirus InfectionsSendai virusSTAT1 Transcription FactorStat1 protein, mouseSTAT1 Transcription Factor

Identifiers

PMID30804041
PMCPMC6456410
OpenAlexW2917084589

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.