Evidence map›Paper›PMID 30804003›Full record

ArticleThe EMBO journal2019

Coordinated calcium signalling in cochlear sensory and non-sensory cells refines afferent innervation of outer hair cells.

Federico Ceriani, Aenea Hendry, Jing-Yi Jeng, Stuart L Johnson, Friederike Stephani, Jennifer Olt, Matthew C Holley, Fabio Mammano, Jutta Engel, Corné J Kros and 2 more

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
5.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 76 citations in OpenAlex.

  1. Article
  2. Spontaneous Calcium Signalling in the Developing Mammalian Cochlea.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. In vivo spontaneous CaNature communications · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Calcium Regulation of Connexin Hemichannels.International journal of molecular sciences · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. CaInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Purinergic Signalling in the Cochlea.International journal of molecular sciences · 2022
    Review
  19. AAV-mediated rescue ofMolecular therapy. Methods & clinical development · 2022
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Federico CerianiDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.ORCID 0000-0002-5366-341X
Aenea HendryDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Jing-Yi JengDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Stuart L JohnsonDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Friederike StephaniCenter for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
Jennifer OltDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Matthew C HolleyDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Fabio MammanoDepartment of Physics and Astronomy "G. Galilei", University of Padua, Padova, Italy.ORCID 0000-0003-3751-1691
Jutta EngelCenter for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, Homburg, Germany.
Corné J KrosSchool of Life Sciences, University of Sussex, Brighton, UK.
Dwayne D SimmonsDepartment of Biology, Baylor University, Waco, TX, USA.
Walter MarcottiDepartment of Biomedical Science, University of Sheffield, Sheffield, UK w.marcotti@sheffield.ac.uk.ORCID 0000-0002-8770-7628
University of Sheffield · GBSaarland University · DEBaylor University · USUniversity of Padua · ITUniversity of Sussex · GB

Funding

Hearing Loss and Calcium RegulationK18DC013304 · NIDCD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SIMMONS, DWAYNE D · 2014 to 2015
$316k
Medical Research Council MR/K005561/1NIDCD NIH HHS K18 DC013304Wellcome Trust 102892/Z/13/Z
6 · The paper itself

Abstract

Outer hair cells (OHCs) are highly specialized sensory cells conferring the fine-tuning and high sensitivity of the mammalian cochlea to acoustic stimuli. Here, by genetically manipulating spontaneous Ca

Indexed as

Afferent PathwaysAction PotentialsAnimalsCalciumCalcium Channels, L-TypeCalcium SignalingCochleaConnexin 30Hair Cells, Auditory, OuterMiceMice, KnockoutMice, TransgenicReceptors, Purinergic P2X3Sensory Receptor CellsSynapsesCacna1d protein, mouseCalciumCalcium Channels, L-TypeConnexin 30Gjb6 protein, mouseReceptors, Purinergic P2X3calcium waveshair cellspre‐hearing developmentpurinergic receptorsspontaneous activity

Identifiers

PMID30804003
PMCPMC6484507
OpenAlexW2915206100

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.