ArticleCancer research2019
Targeted Metabolomics Identifies the Cytochrome P450 Monooxygenase Eicosanoid Pathway as a Novel Therapeutic Target of Colon Tumorigenesis.
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Article in Cancer research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 82 citations in OpenAlex.
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- Liquid Chromatography-Tandem Mass Spectrometry-Based Targeted Lipidomic Analysis of Obesity-Related Colorectal Cancer: Potential Roles of the CYP Eicosanoid Pathway.The Journal of nutrition · 2026Article
- Disturbance of Oxylipin Metabolism Mediated by Autophagy of Mesenteric Adipocytes Orchestrates Gut Inflammation in Crohn's Disease.Cellular and molecular gastroenterology and hepatology · 2026Article
- Regulation of P450-derived epoxy fatty acids in cardiovascular diseases.Redox biochemistry and chemistry · 2025Article
- Emerging analytical techniques for lipid profiling in food products: insights into processing effects and quality control.Food chemistry: X · 2025Review
- Exploring metabolic pathways in gastrointestinal cancer: new evidence of causality.Discover oncology · 2025Article
- Normalizing Body Weight with a Dietary Strategy Mitigates Obesity-Accelerated Pancreatic Carcinogenesis in Mice.The Journal of nutrition · 2025Article
- Saccharomyces cerevisiae SC-2201 Attenuates AOM/DSS-Induced Colorectal Cancer by Modulating the Gut Microbiome and Blocking Proinflammatory Mediators.Probiotics and antimicrobial proteins · 2025Article
- Surface Modification of Gold Nanoparticle Impacts Distinct Lipid Metabolism.Molecules (Basel, Switzerland) · 2025Article
- The Octadecanoids: Synthesis and Bioactivity of 18-Carbon Oxygenated Fatty Acids in Mammals, Bacteria, and Fungi.Chemical reviews · 2025Review
- Metabolic Targets in CRC: The Emerging Role of Cytochrome P450 Inhibitors.Current pharmaceutical design · 2025Review
- Regulating arachidonic acid metabolism: a novel strategy to prevent colorectal inflammatory cancer transformation.Journal of Cancer · 2025Review
- Epoxy metabolites of linoleic acid promote the development of breast cancer via orchestrating PLEC/NFκB1/CXCL9-mediated tumor growth and metastasis.Cell death & disease · 2024Article
- Metabolomics reveals soluble epoxide hydrolase as a therapeutic target for high-sucrose diet-mediated gut barrier dysfunction.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Plant Metabolomics: The Future of Anticancer Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Oxylipins in Aqueous Humor of Primary Open-Angle Glaucoma Patients.Biomolecules · 2024Article
- 5-Fluorouracil in Combination with Calcium Carbonate Nanoparticles Loaded with Antioxidant Thymoquinone against Colon Cancer: Synergistically Therapeutic Potential and Underlying Molecular Mechanism.Antioxidants (Basel, Switzerland) · 2024Article
- Antioxidant Role of Probiotics in Inflammation-Induced Colorectal Cancer.International journal of molecular sciences · 2024Review
- SELENOI Functions as a Key Modulator of Ferroptosis Pathway in Colitis and Colorectal Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
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Authors and funding
24 authors at 8 institutions in 2 countries.
Weicang Wang *Department of Food Science, University of Massachusetts, Amherst, Massachusetts.
Jun Yang *Department of Entomology and Comprehensive Cancer Center, University of California, Davis, California.
Matthew L Edin *Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Yuxin Wang *Department of Food Science, University of Massachusetts, Amherst, Massachusetts.
Ying LuoCenter for Nephrology and Metabolomics and Division of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Debin WanDepartment of Entomology and Comprehensive Cancer Center, University of California, Davis, California.
Haixia YangDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts.
Chun-Qing SongRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts.
Wen XueRNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, Massachusetts.
Katherine Z SanidadDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts.ORCID 0000-0002-2689-3826
Mingyue SongDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts.
Heather A BisbeeMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts.ORCID 0000-0003-0224-9128
Jennifer A BradburyDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina.
Guanjun NanDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts.
Jianan ZhangDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts.
Pei-An Betty ShihDepartment of Psychiatry, University of California, San Diego, La Jolla, California.
Kin Sing Stephen LeeDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan.ORCID 0000-0003-4541-3063
Lisa M MinterMolecular and Cellular Biology Graduate Program, University of Massachusetts, Amherst, Massachusetts.
Daeyoung KimDepartment of Mathematics & Statistics, University of Massachusetts, Amherst, Massachusetts.ORCID 0000-0002-2223-2166
Hang XiaoDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts.
Jun-Yan LiuCenter for Nephrology and Metabolomics and Division of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.ORCID 0000-0002-3018-0335
Bruce D HammockDepartment of Entomology and Comprehensive Cancer Center, University of California, Davis, California. guodongzhang@umass.edu zeldin@niehs.nih.gov bdhammock@ucdavis.edu.
Darryl C ZeldinDivision of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina. guodongzhang@umass.edu zeldin@niehs.nih.gov bdhammock@ucdavis.edu.
Guodong ZhangDepartment of Food Science, University of Massachusetts, Amherst, Massachusetts. guodongzhang@umass.edu zeldin@niehs.nih.gov bdhammock@ucdavis.edu.
University of Massachusetts Amherst · USNational Institute of Environmental Health Sciences · USUniversity of California, Davis · USShanghai Tenth People's Hospital · CNUniversity of Massachusetts Chan Medical School · USMichigan State University · USSouth China Agricultural University · CNUniversity of California San Diego · US
Funding
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1MViral Vector CoreP01HL131471 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FLOTTE, TERENCE R. · 2016 to 2020
$11.3MHYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINSR01ES002710 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1985 to 2018
$4.0MP450 Arachidonate EpoxygenasesZ01ES025034 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI ZELDIN, DARRYL C · 1995 to 2008
$2.2MSolving EPHX2 and PUFA Interactions in Anorexia NervosaR01MH106781 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SHIH, PEI-AN (BETTY) · 2016 to 2020
$2.0MIdentifying the receptors of environmentally sensitive epoxy-eicosanoids with AMSR00ES024806 · NIEHS · MICHIGAN STATE UNIVERSITY · PI LEE, KIN SING STEPHEN · 2017 to 2019
$727kPrevention of colorectal cancer via targeting CYP epoxygenasesR03CA218520 · NCI · UNIVERSITY OF MASSACHUSETTS AMHERST · PI ZHANG, GUODONG · 2018 to 2019
$147kIntramural NIH HHS Z01 ES025034NCI NIH HHS R03 CA218520NHLBI NIH HHS P01 HL131471NIEHS NIH HHS P42 ES004699NIEHS NIH HHS R00 ES024806NIEHS NIH HHS R01 ES002710NIMH NIH HHS R01 MH106781
Abstract
Colon cancer is the third most common cancer and the second leading cause of cancer-related death in the United States, emphasizing the need for the discovery of new cellular targets. Using a metabolomics approach, we report here that epoxygenated fatty acids (EpFA), which are eicosanoid metabolites produced by cytochrome P450 (CYP) monooxygenases, were increased in both the plasma and colon of azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colon cancer mice. CYP monooxygenases were overexpressed in colon tumor tissues and colon cancer cells. Pharmacologic inhibition or genetic ablation of CYP monooxygenases suppressed AOM/DSS-induced colon tumorigenesis
Indexed as
MetabolomicsAnimalsAntifungal AgentsApoptosisAzoxymethaneCarcinogenesisCell ProliferationClotrimazoleColonic NeoplasmsCytochrome P-450 Enzyme SystemDextran SulfateEicosanoidsEnzyme InhibitorsHumansMaleMiceAntifungal AgentsAzoxymethaneClotrimazolecytochrome P-450 CYP2C subfamilyCytochrome P-450 Enzyme SystemDextran SulfateEicosanoidsEnzyme InhibitorsProadifenRNA, Small Interfering
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