Evidence map›Paper›PMID 30803966›Full record

ArticleAntimicrobial agents and chemotherapy2019

A Nationwide Screen of Carbapenem-Resistant Klebsiella pneumoniae Reveals an Isolate with Enhanced Virulence and Clinically Undetected Colistin Heteroresistance.

Jessie E Wozniak, Victor I Band, Andrew B Conley, Lavanya Rishishwar, Eileen M Burd, Sarah W Satola, Dwight J Hardy, Rebecca Tsay, Monica M Farley, Jesse T Jacob and 3 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. mSphere · 2024
    Article
  11. The Rapid Emergence of HypervirulentTropical medicine and infectious disease · 2024
    Review
  12. Heteroresistance to Colistin in Clinical Isolates ofAntibiotics (Basel, Switzerland) · 2023
    Article
  13. Genomic Analysis of Carbapenem-Resistant HypervirulentInfection and drug resistance · 2023
    Article
  14. Prevalence of multidrug-resistant hypervirulentFrontiers in microbiology · 2023
    Article
  15. Article
  16. Article
  17. Relationships between Efflux Pumps and Emergence of Heteroresistance: A Comprehensive Study on the Current Findings.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2022
    Review
  18. Nosocomial dissemination of hypervirulentFrontiers in cellular and infection microbiology · 2022
    Article
  19. Article
  20. Molecular Epidemiology of Hypervirulent Carbapenemase-ProducingFrontiers in cellular and infection microbiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jessie E WozniakEmory University, Atlanta, Georgia, USA.
Victor I BandEmory University, Atlanta, Georgia, USA.
Andrew B ConleyIHRC Applied Bioinformatics Laboratory, Georgia Institute of Technology, Atlanta, Georgia, USA.
Lavanya RishishwarIHRC Applied Bioinformatics Laboratory, Georgia Institute of Technology, Atlanta, Georgia, USA.
Eileen M BurdEmory University School of Medicine, Atlanta, Georgia, USA.
Sarah W SatolaEmory University School of Medicine, Atlanta, Georgia, USA.
Dwight J HardyUniversity of Rochester Medical Center, Rochester, New York, USA.
Rebecca TsayUniversity of Rochester Medical Center, Rochester, New York, USA.
Monica M FarleyEmory University School of Medicine, Atlanta, Georgia, USA.
Jesse T JacobEmory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-9811-6260
Ghinwa DumyatiUniversity of Rochester Medical Center, Rochester, New York, USA.
I King JordanIHRC Applied Bioinformatics Laboratory, Georgia Institute of Technology, Atlanta, Georgia, USA.
David S WeissEmory Vaccine Center, Atlanta, Georgia, USA david.weiss@emory.edu.ORCID 0000-0003-0980-7866

Funding

Mechanisms of phenotypic antibiotic resistance in Gram-negative bacteriaR01AI141883 · NIAID · EMORY UNIVERSITY · PI WEISS, DAVID S · 2018 to 2022
$2.2M
Molecular mechanisms of antibiotic resistance in Acinetobacter baumanniiI01BX002788 · VA · VETERANS HEALTH ADMINISTRATION · PI WEISS, DAVID S · 2016 to 2019
–
BLRD VA I01 BX002788NIAID NIH HHS R01 AI141883
6 · The paper itself

Abstract

The convergence of hypervirulence and multidrug resistance in

Indexed as

Carbapenem-Resistant EnterobacteriaceaeCarbapenemsColistinDrug Resistance, BacterialGenotypeKlebsiella pneumoniaeMicrobial Sensitivity TestsVirulenceCarbapenemsColistincolistinheteroresistancehypermucoviscousKlebsiellaKPC

Identifiers

PMID30803966
PMCPMC6496084

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.