Trial reportClinical radiology2019
Breast arterial calcification on mammography and risk of coronary artery disease: a SCOT-HEART sub-study.
Trial report in Clinical radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of Breast Arterial Calcification and Its Association With Cardiovascular Disease and All-Cause Mortality.The American journal of cardiology · 2026Pooled it
- Association Between Breast Arterial Calcification on Mammography and Coronary Artery Disease: A Systematic Review and Meta-Analysis.Journal of women's health (2002) · 2022Pooled it
- Is breast arterial calcification associated with coronary artery disease?-A systematic review and meta-analysis.PloS one · 2020Pooled it
- Review
- Breast Arterial Calcifications on Mammography: A Review of the Literature.Journal of breast imaging · 2025Review
- Breast Arterial Calcification on a Screening Mammogram: A Potential Cardiovascular Risk Stratification Tool in Women.Reviews in cardiovascular medicine · 2025Review
- Automated Breast Arterial Calcification Score Is Associated With Cardiovascular Outcomes and Mortality.JACC. Advances · 2024Article
- Does the absence of breast arterial calcification (BAC 0) rule out severe coronary artery disease? A computed tomography angiography study.American journal of preventive cardiology · 2024Article
- Recurrent attention U-Net for segmentation and quantification of breast arterial calcifications on synthesized 2D mammograms.PeerJ. Computer science · 2024Article
- Automated classification of fat-infiltrated axillary lymph nodes on screening mammograms.The British journal of radiology · 2023Article
- The association between breast arterial calcification and atherosclerotic cardiovascular disease in an Australian population-based breast cancer case-control study.La Radiologia medica · 2023Article
- Relationship between Arterial Calcifications on Mammograms and Cardiovascular Events: A Twenty-Three Year Follow-Up Retrospective Cohort Study.Biomedicines · 2022Article
- Leveraging Mammography as a Unique Opportunity for Cardiovascular Health Promotion.Circulation. Cardiovascular imaging · 2022Article
- Breast Arterial Calcifications on Mammography among Patients Attending the Radiology Department in a Tertiary Care Centre: A Descriptive Cross-sectional Study.JNMA; journal of the Nepal Medical Association · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
aimTo assess the prevalence of breast arterial calcification (BAC) in patients who also underwent routine surveillance mammography, and to determine the association with cardiovascular risk factors, coronary artery calcification, and coronary artery disease on coronary computed tomography angiography (CCTA). MATERIALS AND
methodsFour hundred and five female participants were identified who had undergone CCTA and subsequent mammography in the SCOT-HEART randomised controlled trial of CCTA in patients with suspected stable angina. Mammograms were assessed visually for the presence and severity of BAC.
resultsBAC was identified in 93 (23%) patients. Patients with BAC were slightly older (63±7 versus 59±8 years, p<0.001), with a higher cardiovascular risk score (19±11 versus 16±10, p=0.022) and were more likely to be non-smokers (73% versus 49%, p<0.001). In patients with BAC, coronary artery calcification was present in 58 patients (62%; relative risk [RR] 1.26, 95% confidence intervals [CI]: 1.04, 1.53; p=0.02), non-obstructive coronary artery disease in 58 (62%; RR 1.27, 95% CI: 1.04 to 1.54, p=0.02), and obstructive coronary artery disease in 19 (20%; RR 1.62, 95% CI: 0.98, 2.66; p=0.058). Patients without BAC were very unlikely to have severe coronary artery calcification (negative predictive value 95%) but the diagnostic accuracy of BAC to identify coronary artery disease was poor (AUC 0.547).
conclusionAlthough BAC is associated with the presence and severity of coronary artery calcification, the diagnostic accuracy to identify patients with coronary artery disease or obstructive coronary artery disease is poor.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.