ArticleJournal of the American Dental Association (1939)2019
Pharmacokinetics of 38% topical silver diamine fluoride in healthy adult volunteers.
Article in Journal of the American Dental Association (1939), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pharmacokinetics of Advantage Arrest
The Pharmacokinetics of Silver Diamine Fluoride (SDF) in Healthy Children
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Fluoride Intake Through Dental Care Products: A Systematic Review.Frontiers in oral health · 2022Pooled it
- Tooth Discoloration from 2 Silver Fluorides Used in Adults with Special Needs: A Randomized Trial.JDR clinical and translational research · 2025Trial
- Silver diamine fluoride for non-operative restorative treatment and prevention of dental caries.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2026Review
- Efficacy of topical strategies to prevent the onset of root caries lesions: an in vitro study.Odontology · 2026Article
- The pharmacokinetics of 38% silver diamine fluoride in healthy children with dental caries: a quasi-experimental study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2023Article
- Effectiveness of silver diamine fluoride 38% on reduction of gingivitis in dogs: a randomized clinical trial.Frontiers in veterinary science · 2023Article
- Pharmacokinetics of 38 Percent Silver Diamine Fluoride in Children.Pediatric dentistry · 2022Article
- Revisiting Fluoride in the Twenty-First Century: Safety and Efficacy Considerations.Frontiers in oral health · 2022Article
- Silver Modified Atraumatic Restorative Technique: A Way towards "SMART" Pediatric Dentistry during the COVID-19 Pandemic.Frontiers in dentistry · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSilver diamine fluoride (SDF) is used topically to prevent or arrest caries. The authors' aim was to characterize the kinetics of silver and fluoride after topical application of SDF.
methodsSixteen adults participated in a pharmacokinetics study after the application of 38% SDF to 5 teeth (approximately 50 microliters, estimated 4-11 milligrams per participant). Serum and urine samples were collected over 24 hours after application and were analyzed for silver and fluoride.
resultsSilver serum peak was 0.67 (standard deviation [SD], 0.49) nanograms per milliliter; median time to peak was 3 hours. The estimated elimination half-life of silver was 46 (SD, 26) hours. No silver was recovered in urine. Baseline fluoride serum levels ranged from less than 10 through 50 ng/mL (< 0.01-0.05 parts per million) and fluctuated around baseline after SDF. The 24-hour urinary fluoride was 1.29 (SD, 0.81) mg.
conclusionsSDF was well tolerated in this study, and no adverse events related to SDF were reported. PRACTICAL IMPLICATIONS: This clinical study confirmed that topical application of 38% SDF, in growing use in the United States, is safe and well tolerated in healthy adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.