Evidence map›Paper›PMID 30803367›Full record

ArticleTechnology in cancer research & treatment2019

Evaluation and Clinical Application of a Commercially Available Iterative Reconstruction Algorithm for CBCT-Based IGRT.

Weihua Mao, Chang Liu, Stephen J Gardner, Farzan Siddiqui, Karen C Snyder, Akila Kumarasiri, Bo Zhao, Joshua Kim, Ning Winston Wen, Benjamin Movsas and 1 more

Abstract readEvaluation Study
In one paragraph

Article in Technology in cancer research & treatment, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
  3. HyperSightRadiation oncology (London, England) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Weihua Mao1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.ORCID 0000-0001-5985-4244
Chang Liu1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Stephen J Gardner1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Farzan Siddiqui1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Karen C Snyder1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Akila Kumarasiri1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Bo Zhao1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Joshua Kim1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Ning Winston Wen1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Benjamin Movsas1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.
Indrin J Chetty1 Department of Radiation Oncology, Henry Ford Health System, Detroit, MI, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe have quantitatively evaluated the image quality of a new commercially available iterative cone-beam computed tomography reconstruction algorithm over standard cone-beam computed tomography image reconstruction results.

methodsThis iterative cone-beam computed tomography reconstruction pipeline uses a finite element solver (AcurosCTS)-based scatter correction and a statistical (iterative) reconstruction in addition to a standard kernel-based correction followed by filtered back-projection-based Feldkamp-Davis-Kress cone-beam computed tomography reconstruction. Standard full-fan half-rotation Head, half-fan full-rotation Head, and standard Pelvis cone-beam computed tomography protocols have been investigated to scan a quality assurance phantom via the following image quality metrics: uniformity, HU constancy, spatial resolution, low contrast detection, noise level, and contrast-to-noise ratio. An anthropomorphic head phantom was scanned for verification of noise reduction. Clinical patient image data sets for 5 head/neck patients and 5 prostate patients were qualitatively evaluated.

resultsQuality assurance phantom study results showed that relative to filtered back-projection-based cone-beam computed tomography, noise was reduced from 28.8 ± 0.3 HU to a range between 18.3 ± 0.2 and 5.9 ± 0.2 HU for Full-Fan Head scans, from 14.4 ± 0.2 HU to a range between 12.8 ± 0.3 and 5.2 ± 0.3 HU for Half-Fan Head scans, and from 6.2 ± 0.1 HU to a range between 3.8 ± 0.1 and 2.0 ± 0.2 HU for Pelvis scans, with the iterative cone-beam computed tomography algorithm. Spatial resolution was marginally improved while results for uniformity and HU constancy were similar. For the head phantom study, noise was reduced from 43.6 HU to a range between 24.8 and 13.0 HU for a Full-Fan Head and from 35.1 HU to a range between 22.9 and 14.0 HU for a Half-Fan Head scan. The patient data study showed that artifacts due to photon starvation and streak artifacts were all reduced, and image noise in specified target regions were reduced to 62% ± 15% for 10 patients.

conclusionNoise and contrast-to-noise ratio image quality characteristics were significantly improved using the iterative cone-beam computed tomography reconstruction algorithm relative to the filtered back-projection-based cone-beam computed tomography method. These improvements will enhance the accuracy of cone-beam computed tomography-based image-guided applications.

Indexed as

AlgorithmsPhantoms, ImagingCone-Beam Computed TomographyHeadHead and Neck NeoplasmsHumansImage Processing, Computer-AssistedMalePelvisProstatic NeoplasmsRadiotherapy, Intensity-ModulatedRadiotherapy Planning, Computer-AssistedCBCTiterative reconstructionlow contrast detectionnoise reductionscatter correction

Identifiers

PMID30803367
PMCPMC6373994

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.