ArticleJournal of biological rhythms2019
Nocturnal Melatonin Suppression by Adolescents and Adults for Different Levels, Spectra, and Durations of Light Exposure.
Article in Journal of biological rhythms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07661966 (A Pilot Trial of Bright Light Therapy in Patients Receiving First Line Immune Checkpoint Blockade), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Pilot Trial of Bright Light Therapy in Patients Receiving First Line Immune Checkpoint Blockade
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Circadian light therapy and light dose for depressed young people: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Associations between physical activity and sedentary time with sleep duration and sleep quality in adolescents.BMC public health · 2026Article
- Article
- Light Exposure Rhythms and Sleep Organization in Adolescents: Temporal Differences Between Weekdays and Weekends in an Actigraphic Study.Clocks & sleep · 2026Article
- Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications.Frontiers in sleep · 2026Review
- Individual-Level Exposure to Light at Night and Sleep Health: A Comparison between Real-Time Mobility-Based Measurements and Indoor Residence-Based Measurements.Environmental science & technology · 2025Article
- Afternoon to early evening bright light exposure reduces later melatonin production in adolescents.Npj biological timing and sleep · 2025Article
- Melatonin Secretion and Impacts of Training and Match Schedules on Sleep Quality, Recovery, and Circadian Rhythms in Young Professional Football Players.Biomolecules · 2025Article
- Circadian lighting effect for inpatients with schizophrenia: A prospective cohort study.Brain and behavior · 2024Article
- Power Analysis for Human Melatonin Suppression Experiments.Clocks & sleep · 2024Article
- Effects of evening smartphone use on sleep and declarative memory consolidation in male adolescents and young adults.Brain communications · 2024Article
- Days to re-entrainment following the spring and autumn changes in local clock time: Beyond simple heuristics.Frontiers in photonics · 2024Article
- Numerical correlation between non-visual metrics and brightness metrics-implications for the evaluation of indoor white lighting systems in the photopic range.Scientific reports · 2023Article
- Influence of the Human Field of View on Visual and Non-Visual Quantities in Indoor Environments.Clocks & sleep · 2023Article
- Long wavelength light reduces the negative consequences of dim light at night.Neurobiology of disease · 2023Article
- Continuous Versus Intermittent Nutrition in Pediatric Intensive Care Patients: Protocol for a Randomized Controlled Trial.JMIR research protocols · 2022Article
- Diurnal Circadian Lighting Accumulation Model: A Predictor of the Human Circadian Phase Shift Phenotype.Phenomics (Cham, Switzerland) · 2022Article
- Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures.Neurobiology of sleep and circadian rhythms · 2021Article
- Modeling Circadian Phototransduction: Quantitative Predictions of Psychophysical Data.Frontiers in neuroscience · 2021Article
- Correlated color temperature and light intensity: Complementary features in non-visual light field.PloS one · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The human circadian system is primarily regulated by the 24-h LD cycle incident on the retina, and nocturnal melatonin suppression is a primary outcome measure for characterizing the biological clock's response to those light exposures. A limited amount of data related to the combined effects of light level, spectrum, and exposure duration on nocturnal melatonin suppression has impeded the development of circadian-effective lighting recommendations and light-treatment methods. The study's primary goal was to measure nocturnal melatonin suppression for a wide range of light levels (40 to 1000 lux), 2 white light spectra (2700 K and 6500 K), and an extended range of nighttime light exposure durations (0.5 to 3.0 h). The study's second purpose was to examine whether differences existed between adolescents' and adults' circadian sensitivity to these lighting characteristics. The third purpose was to provide an estimate of the absolute threshold for the impact of light on acute melatonin suppression. Eighteen adolescents (age range, 13 to 18 years) and 23 adults (age range, 24 to 55 years) participated in the study. Results showed significant main effects of light level, spectrum, and exposure duration on melatonin suppression. Moreover, the data also showed that the relative suppressing effect of light on melatonin diminishes with increasing exposure duration for both age groups and both spectra. The present results do not corroborate our hypothesis that adolescents exhibit greater circadian sensitivity to short-wavelength radiation compared with adults. As for threshold, it takes longer to observe significant melatonin suppression at lower CS levels than at higher CS levels. Dose-response curves (amount and duration) for both white-light spectra and both age groups can guide lighting recommendations when considering circadian-effective light in applications such as offices, schools, residences, and healthcare facilities.
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