ArticleThe Journal of international medical research2019
Association of ENAM, TUFT1, MMP13, IL1B, IL10 and IL1RN gene polymorphism and dental caries susceptibility in Chinese children.
Article in The Journal of international medical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- [Polymorphisms associated with dental caries in pediatric populations: a systematic review].Revista medica del Instituto Mexicano del Seguro Social · 2023Pooled it
- miR-155 rs767649 polymorphism contributes to dental caries susceptibility of Chinese Han children.Odontology · 2026Article
- Allelic and Genotypic Distribution ofClinics and practice · 2025Article
- Polymorphisms inThe Saudi dental journal · 2024Article
- A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries andDentistry journal · 2024Article
- Estimation and Correlation of Alkaline Phosphatase Enzymatic Activity in Saliva with and without Early Childhood Caries in South Indian Children: A Randomized Clinical Trial.International journal of clinical pediatric dentistry · 2024Article
- The association betweenHealth science reports · 2023Article
- Association of polymicrobial interactions with dental caries development and prevention.Frontiers in microbiology · 2023Review
- Association of genetic variants in enamel-formation genes with dental caries: A meta- and gene-cluster analysis.Saudi journal of biological sciences · 2021Article
- Multivariate GWAS of Structural Dental Anomalies and Dental Caries in a Multi-Ethnic Cohort.Frontiers in dental medicine · 2021Article
- Lack of associations between lactoferrin (The Journal of international medical research · 2020Article
- Matrix metalloproteinases gene variants and dental caries in Czech children.BMC oral health · 2020Article
- Tuftelin and HIFs expression in osteogenesis.Histochemistry and cell biology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between single nucleotide polymorphisms (SNPs) in six candidate genes (enamelin [ ENAM]; tuftelin 1 [ TUFT1]; matrix metallopeptidase 13 [ MMP13]; interleukin 1 beta [ IL1B]; interleukin 10 [ IL10]; interleukin 1 receptor antagonist [ IL1RN]) and dental caries in children from northwest China.
methodsThis case-control study enrolled children (12-15 years) who underwent routine dental examinations. The children were divided into two groups based on the presence of dental caries. A saliva sample was collected and seven SNPs (rs3806804A/G in ENAM, rs3811411T/G in TUFT1, rs2252070A/G and rs597315A/T in MMP13, rs1143627C/T in IL1B, rs1800872A/C in IL10 and rs956730G/A in IL1RN) were genotyped.
resultsA total of 357 children were enrolled in the study: 161 with dental caries and 196 without dental caries. No significant difference was found in the alleles and genotypes of five genes ( ENAM, TUFT1, MMP13, IL10 and IL1RN) between those with and without dental caries. A significant relationship was found between the IL1B rs1143627C/T polymorphism and dental caries susceptibility with those carrying the rs1143627CT genotype having a lower risk of dental caries compared with those carrying the CC genotype (odds ratio 0.557; 95% confidence interval 0.326, 0.952).
conclusionThe IL1B rs1143627C/T polymorphism may be associated with dental caries susceptibility in children from northwest China.
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