Evidence map›Paper›PMID 30803263›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2019

Human-relevant preclinical in vitro models for studying hepatobiliary development and liver diseases using induced pluripotent stem cells.

Pooja Chaudhari, Lipeng Tian, Zhaohui Ye, Yoon-Young Jang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A CYP3A7 metabolically competent human induced pluripotent stem cell-derived hepatocyte-like cell (hHLCDrug metabolism and disposition: the biological fate of chemicals · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Pooja Chaudhari1 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA.
Lipeng Tian1 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA.
Zhaohui Ye3 Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Yoon-Young Jang1 Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD 21205, USA.

Funding

Real Time Elucidation of Drug-Drug Interactions via Dual Reporter Cell Technology and Microfabricated ArraysR01EB023812 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET, YARMUSH, MARTIN L · 2016 to 2019
$1.8M
A human iPSC-based model of Biliary AtresiaR03HD091264 · NICHD · JOHNS HOPKINS UNIVERSITY · PI JANG, YOON YOUNG · 2018 to 2019
$164k
NIBIB NIH HHS R01 EB023812NICHD NIH HHS R03 HD091264
6 · The paper itself

Abstract

impact statementIn this review, we address the potential of human-induced pluripotent stem cell-based hepatobiliary differentiation technology as a means to study human liver development and cell fate determination, and to model liver diseases in an effort to develop a new human-relevant preclinical platform for drug development.

Indexed as

Adaptor Proteins, Signal TransducingAdultAnimalsBile DuctsCell DifferentiationCell LineChemical and Drug Induced Liver InjuryDrug DevelopmentDrug Evaluation, PreclinicalEmbryoid BodiesHedgehog ProteinsHepatocytesHumansInduced Pluripotent Stem CellsIn Vitro TechniquesLiverAdaptor Proteins, Signal TransducingHedgehog ProteinsTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinshepatobiliary developmentHuman-induced pluripotent stem cellliver diseaseYAP

Identifiers

PMID30803263
PMCPMC6552401

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.