Evidence map›Paper›PMID 30803095›Full record

ArticlePsycho-oncology2019

A preventive intervention to modify depression risk targets after breast cancer diagnosis: Design and single-arm pilot study.

Karen L Weihs, Mairead H McConnell, Joshua F Wiley, Catherine M Crespi, Shannon Sauer-Zavala, Annette L Stanton

Abstract read
In one paragraph

Article in Psycho-oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. The utility of coping through emotional approach: A meta-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2024
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Karen L WeihsDepartment of Psychiatry, University of Arizona, Tucson, Arizona.ORCID 0000-0001-5985-8560
Mairead H McConnellDepartment of Psychology, University of Arizona, Tucson, Arizona.
Joshua F WileySchool of Psychological Sciences, Monash University, Melbourne, Victoria.
Catherine M CrespiDepartment of Biostatistics, UCLA Fielding School of Public Health, Los Angeles, California.
Shannon Sauer-ZavalaDepartment of Psychological and Brain Sciences, Boston University, Boston, Massachusetts.
Annette L StantonDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
University of Arizona · USBoston University · USMonash University · AUUCLA Health · USUniversity of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
VITAMIN AP30CA023074 · NCI · UNIVERSITY OF ARIZONA · PI Dan Theodorescu · 1985 to 2026
$110.2M
Emotion Regulation and Depression in Breast Cancer SurvivorshipR01CA133081 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI STANTON, ANNETTE L, WEIHS, KAREN L. · 2009 to 2014
$2.9M
NCI NIH HHS NCI-NIH P30CA023074NCI NIH HHS NCI-NIH P30 CA 16042NCI NIH HHS NIH R01 CA133081NCI NIH HHS P30 CA016042NCI NIH HHS P30 CA023074NCI NIH HHS R01 CA133081
6 · The paper itself

Abstract

objectiveApply the National Institutes of Health (NIH) Stage Model to design and test an intervention to prevent depression in breast cancer patients at risk for depression.

methodsWe identified mindful emotion awareness, along with approach and avoidance strategies for cancer-related coping and emotion regulation, as targets for a preventive intervention adapted from the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders. Patients' preferences for individual, in-person, and time-efficient sessions informed the design. Patients at risk for depression received a 6-week, 5-hour intervention with daily exercises. Intervention targets were assessed at baseline, before each session, and 4-weeks post intervention. Mixed effects analysis of variance (ANOVA) assessed change over the follow-up period, controlling for age, partnered status, and disease stage.

resultsFifty-five percent (40/72) of women screened within 6 months of diagnosis had elevated depression risk. Of these, 24 (60%) signed consent. Sixteen received intervention after five were excluded for current depressive disorder, cognitive impairment, or death. Three dropped out. Ninety-eight percent attendance and 77% practice days indicated feasibility. Effect sizes (Cohen's d) corrected for regression to the mean (RTM) were 0.82 for cancer-related acceptance coping, 0.65 for cancer-related emotional expression, and 0.32 and 0.42 for decreased cancer-related avoidance coping and depressive symptoms, respectively. Effect sizes for variables lacking data to correct for RTM were 1.0, 0.7, and 0.5 for decreased rumination, experiential avoidance, and fear of depression, respectively, and 1.3, 0.6, and 0.4 for increased cognitive flexibility, distress tolerance, and describing/not judging emotions, respectively.

conclusionsThe feasibility of this intervention and malleability of its targets support its further investigation.

Indexed as

MindfulnessAdaptation, PsychologicalAdultBreast NeoplasmsDepressionFemaleHumansMiddle AgedPilot ProjectsQuality of Lifebreast cancercopingdepressioninterventiononcologyprevention

Identifiers

PMID30803095
PMCPMC6445679
OpenAlexW2917754680

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.