ArticleFEBS letters2019
The impact of Megf10/Drpr gain-of-function on muscle development in Drosophila.
Article in FEBS letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- The Notch signaling pathway in skeletal muscle health and disease.Muscle & nerve · 2022Review
- Depletion of skeletal muscle satellite cells attenuates pathology in muscular dystrophy.Nature communications · 2022Article
- Implications of notch signaling in duchenne muscular dystrophy.Frontiers in physiology · 2022Review
- A form of muscular dystrophy associated with pathogenic variants in JAG2.American journal of human genetics · 2021Article
- Megf10 deficiency impairs skeletal muscle stem cell migration and muscle regeneration.FEBS open bio · 2021Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Recessive mutations in multiple epidermal growth factor-like domains 10 (MEGF10) underlie a rare congenital muscle disease known as MEGF10 myopathy. MEGF10 and its Drosophila homolog Draper (Drpr) are transmembrane receptors expressed in muscle and glia. Drpr deficiency is known to result in muscle abnormalities in flies. In the current study, flies that ubiquitously overexpress Drpr, or mouse Megf10, display developmental arrest. The phenotype is reproduced with overexpression in muscle, but not in other tissues, and with overexpression during intermediate stages of myogenesis, but not in myoblasts. We find that tubular muscle subtypes are particularly sensitive to Megf10/Drpr overexpression. Complementary genetic analyses show that Megf10/Drpr and Notch may interact to regulate myogenesis. Our findings provide a basis for investigating MEGF10 in muscle development using Drosophila.
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Registered trials
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