Evidence map›Paper›PMID 30802639›Full record

ArticleBiochimica et biophysica acta. Molecular basis of disease2019

Mutant huntingtin inhibits the mitochondrial unfolded protein response by impairing ABCB10 mRNA stability.

Zixing Fu, Fang Liu, Chunyue Liu, Beifang Jin, Yueqing Jiang, Mingliang Tang, Xin Qi, Xing Guo

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimica et biophysica acta. Molecular basis of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
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  4. Article
  5. Chaperonin in health and disease.Molecular biomedicine · 2026
    Review
  6. Molecular mechanisms of mitochondrial AAA+ proteases.The Journal of biological chemistry · 2026
    Review
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  11. Article
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  15. Article
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  17. Article
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  19. Review
  20. UPRBiochemical and biophysical research communications · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Zixing FuDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
Fang LiuDepartment of Anatomy, College of Basic Medicine, Guilin Medical University, Guilin 541004, China.
Chunyue LiuDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
Beifang JinDepartment of Anatomy, College of Basic Medicine, Guilin Medical University, Guilin 541004, China.
Yueqing JiangDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 211166, Jiangsu, China.
Mingliang TangKey Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing 210096, China.
Xin QiDepartment of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA; Center for Mitochondrial Disease, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. Electronic address: xxq38@case.edu.
Xing GuoDepartment of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing 211166, Jiangsu, China. Electronic address: guox@njmu.edu.cn.
Nanjing Medical University · CNGuilin Medical University · CNSoutheast University · CNUniversity School · US

Funding

Dynamin-related protein 1, neurodegeneration and Huntington's diseaseR01NS088192 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI QI, XIN · 2014 to 2018
$1.7M
NINDS NIH HHS R01 NS088192
6 · The paper itself

Abstract

Numerous studies have shown that mitochondrial dysfunction contributes to consequential phenotypes of Huntington's disease (HD), a fatal and inherited neurodegenerative disease caused by the expanded CAG repeats in the N-terminus of the huntingtin (Htt) gene. To maintain proper function, mitochondria develop a dedicated protein quality control mechanism by activating a stress response termed the mitochondrial unfolded protein response (UPR

Indexed as

Unfolded Protein ResponseAnimalsATP-Binding Cassette TransportersCell DeathCell LineChaperonin 60Corpus StriatumEndopeptidase ClpFibroblastsGene Expression RegulationHumansHuntingtin ProteinHuntington DiseaseMiceMice, TransgenicMitochondriaABCB10 protein, humanATP-Binding Cassette TransportersChaperonin 60ClpP protein, humanDDIT3 protein, humanEndopeptidase ClpHSPD1 protein, humanHTT protein, humanHuntingtin ProteinMitochondrial ProteinsRNA, MessengerTranscription Factor CHOPABCB10Huntington's diseaseMitochondrial dysfunctionMitochondrial unfolded protein response

Identifiers

PMID30802639
PMCPMC6502650
OpenAlexW2915546981

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.