Observational studyOsteoarthritis and cartilage2019
Spatial distribution and temporal progression of T2 relaxation time values in knee cartilage prior to the onset of cartilage lesions - data from the Osteoarthritis Initiative (OAI).
Observational study in Osteoarthritis and cartilage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Evaluation of Pre-Operative Cartilage and Meniscus Ultrashort Echo Time T2* as Biomarkers of Long-Term Clinical Outcomes Following Anterior Cruciate Ligament Reconstruction.Journal of magnetic resonance imaging : JMRI · 2026Article
- Prospective study assessing the validity of accelerated 2D Fast Spin Echo (2D FSE) based high-resolution knee MRI and T2 mapping using deep learning reconstruction.BMC musculoskeletal disorders · 2026Article
- Large Separable Kernel Attention-Driven Multidimensional Feature Cross-Level Fusion Classification Network of Knee Cartilage Injury: Algorithm Development and Validation.JMIR medical informatics · 2025Article
- Association between constant and intermittent knee pain and T2 values and cartilage thickness: data from the osteoarthritis initiative.Arthritis research & therapy · 2025Article
- Improving Accuracy and Reproducibility of Cartilage TJournal of magnetic resonance imaging : JMRI · 2025Article
- Foundations of a knee joint digital twin from qMRI biomarkers for osteoarthritis and knee replacement.NPJ digital medicine · 2025Article
- Reproducibility of Quantitative Double-Echo Steady-State TJournal of magnetic resonance imaging : JMRI · 2025Article
- Gaining Insight into Updated MR Imaging for Quantitative Assessment of Cartilage Injury in Knee Osteoarthritis.Current rheumatology reports · 2024Review
- Cartilage compositional MRI-a narrative review of technical development and clinical applications over the past three decades.Skeletal radiology · 2024Review
- Clinical and imaging findings associated with preservation of knee joint health over 8 years in individuals aged 65 and over: data from the OAI.BMC musculoskeletal disorders · 2024Article
- MRI-based TSkeletal radiology · 2023Review
- T2 mapping magnetic resonance imaging of cartilage in hemophilia.Research and practice in thrombosis and haemostasis · 2023Article
- Spatial Gradients of Quantitative MRI as Biomarkers for Early Detection of Osteoarthritis: Data From Human Explants and the Osteoarthritis Initiative.Journal of magnetic resonance imaging : JMRI · 2023Article
- Insights into the Age Dependency of Compositional MR Biomarkers Quantifying the Health Status of Cartilage in Metacarpophalangeal Joints.Diagnostics (Basel, Switzerland) · 2023Article
- Early knee OA definition-what do we know at this stage? An imaging perspective.Therapeutic advances in musculoskeletal disease · 2023Review
- Predicting osteoarthritis onset and progression with 3D texture analysis of cartilage MRI DESS: 6-Year data from osteoarthritis initiative.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- FDA/Arthritis Foundation osteoarthritis drug development workshop recap: Assessment of long-term benefit.Seminars in arthritis and rheumatism · 2022Review
- Fast, Accurate, and Robust T2 Mapping of Articular Cartilage by Neural Networks.Diagnostics (Basel, Switzerland) · 2022Article
- Patellar instability MRI measurements are associated with knee joint degeneration after reconstruction of the medial patellofemoral ligament.Skeletal radiology · 2022Article
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Abstract
purposeTo investigate compositional changes of knee cartilage at the site of newly appearing cartilage lesions and the surrounding cartilage 1-4 years prior to lesion onset using quantitative T2-measurements.
methodsFifty-seven cartilage plates with newly appearing cartilage lesions from 45 knees (cases) and 52 plates from 26 control knees from the Osteoarthritis Initiative (OAI) cohort (controls) were evaluated. Using MRI T2-mapping, composition of local (the site of future lesions) and surrounding cartilage (remainder of the cartilage plate) was assessed 1-4 years prior to lesion onset. Analogous cartilage ROIs in control plates without cartilage lesions were assessed over 1-4 years. Mixed models were used to compare T2-means and change rates between local and surrounding cartilage within cases and controls, and to compare change rates in local and surrounding cartilage between cases and controls, adjusting for covariates.
resultsFour years prior to lesion onset, we found that local cartilage ROIs had higher T2-values compared to the surrounding cartilage. No such differences were found in control plates. In cases mean local T2-values were persistantly elevated compared to the surrounding cartilage prior to lesion onset reaching significance 1 year prior (+2.94 ms, p = 0.012). T2-values of the surrounding cartilage were also persistantly higher in cases compared to controls, reaching significance 2 years prior to lesion onset (+3.61 ms, p = 0.003).
conclusionThe findings of our study support the concept of compositional cartilage changes as a mechanism for cartilage degradation and that both diffuse and focal changes of cartilage composition within a cartilage plate precede the development of cartilage lesions.
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