Evidence map›Paper›PMID 30802460›Full record

ReviewProgress in cardiovascular diseases

Are the neuroprotective effects of exercise training systemically mediated?

Atefe R Tari, Cecilie S Norevik, Nathan R Scrimgeour, Asgeir Kobro-Flatmoen, Jon Storm-Mathisen, Linda H Bergersen, Christiane D Wrann, Geir Selbæk, Miia Kivipelto, José Bianco N Moreira and 1 more

Open access · hybridAbstract readReview
PubMed Publisher
In one paragraph

Review in Progress in cardiovascular diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 4 pooled it
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 4 syntheses or guidelines pooled it, 115 citations in OpenAlex.

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  14. Physical activity mediates age differences in cognition among Tsimane forager-horticulturalists.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 5 countries.

Atefe R TariThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway; Department of Neurology, St. Olavs Hospital, Trondheim, Norway. Electronic address: atefe.r.tari@ntnu.no.
Cecilie S NorevikThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway; Department of Neurology, St. Olavs Hospital, Trondheim, Norway.
Nathan R ScrimgeourThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway.
Asgeir Kobro-FlatmoenKavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Norwegian University of Science and Technology, Norway.
Jon Storm-MathisenDepartment of Molecular Medicine, University of Oslo, Norway.
Linda H BergersenDepartment of Oral Biology, University of Oslo, Norway.
Christiane D WrannMassachusetts General Hospital and Harvard Medical School, Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, United States of America.
Geir SelbækNorwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway; Institute of Health and Society, Faculty of Medicine, University of Oslo, Oslo, Norway; Research Centre for Age-related Functional Decline and Disease, Innlandet Hospital Trust, Ottestad, Norway.
Miia KivipeltoDivision of Clinical Geriatrics, Center for Alzheimer Research, Karolinska Institute, Stockholm, Sweden; Department of Neurology, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland; Age and Epidemiology Research Unit, School of Public Health, Imperial College London, UK.
José Bianco N MoreiraThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway.
Ulrik WisløffThe Cardiac Exercise Research Group at Department of Circulation and Medical Imaging, The Norwegian University of Science and Technology, Norway.
Norwegian University of Science and Technology · NOUniversity of Oslo · NOInnlandet Hospital Trust · NOKarolinska Institutet · SEMassachusetts General Hospital · USSt Olav's University Hospital · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date there is no cure available for dementia, and the field calls for novel therapeutic targets. A rapidly growing body of literature suggests that regular endurance training and high cardiorespiratory fitness attenuate cognitive impairment and reduce dementia risk. Such benefits have recently been linked to systemic neurotrophic factors induced by exercise. These circulating biomolecules may cross the blood-brain barrier and potentially protect against neurodegenerative disorders such as Alzheimer's disease. Identifying exercise-induced systemic neurotrophic factors with beneficial effects on the brain may lead to novel molecular targets for maintaining cognitive function and preventing neurodegeneration. Here we review the recent literature on potential systemic mediators of neuroprotection induced by exercise. We focus on the body of translational research in the field, integrating knowledge from the molecular level, animal models, clinical and epidemiological studies. Taken together, the current literature provides initial evidence that exercise-induced, blood-borne biomolecules, such as BDNF and FNDC5/irisin, may be powerful agents mediating the benefits of exercise on cognitive function and may form the basis for new therapeutic strategies to better prevent and treat dementia.

Indexed as

DementiaCardiorespiratory FitnessCognitionEndurance TrainingExerciseHumansNerve Growth FactorsNeuroprotectionNerve Growth FactorsAlzheimer's diseaseCardiorespiratory fitnessDementiaExercise-induced blood-borne factorsPhysical activity

Identifiers

PMID30802460
OpenAlexW2917053521

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.