ArticleHuman brain mapping2019
Searching for the neurite density with diffusion MRI: Challenges for biophysical modeling.
Article in Human brain mapping, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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81 citing papers in PubMed.
- Implementation and validation of a clinically compatible four-shell diffusion MRI protocol for ischemic stroke research.MethodsX · 2026Article
- Evaluating the Influence of Injury-Induced Microstructural Variations on the Efficacy of a Diffusion MRI-Derived Axon Diameter Surrogate.Magnetic resonance in medicine · 2026Article
- Informed Dictionary-Guided Monte Carlo Inversion for Robust and Reproducible Multidimensional MRI.Magnetic resonance in medicine · 2026Article
- Thermal noise lowers the accuracy of rotationally invariant harmonics of diffusion MRI data and their robustness to experimental variations.Magnetic resonance in medicine · 2026Article
- Myelin water and tensor-valued diffusion imaging: (How) are they related?Magnetic resonance in medicine · 2025Article
- Diffusion MRI in the cortex of the brain: Reducing partial volume effects from CSF and white matter in the mean diffusivity using high b-values and spherical b-tensor encoding.Magnetic resonance in medicine · 2025Article
- Multi-TE Diffusion MRI Dataset for Exploring Combined Diffusion-Relaxometry Methods in Microstructure Imaging.Scientific data · 2025Article
- Comparison of different neurite density metrics with brain asymmetry evaluation.Zeitschrift fur medizinische Physik · 2025Article
- Multidimensional MRI reveals cortical astrogliosis linked to dementia in Alzheimer's disease.Brain communications · 2025Article
- Joint estimation of compartment-specific TMagnetic resonance in medicine · 2025Article
- Detecting glioblastoma infiltration beyond conventional imaging tumour margins using MTE-NODDI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Linking microscopy to diffusion MRI with degenerate biophysical models: An application of the Bayesian EstimatioN of CHange (BENCH) framework.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Interplay between MRI-based axon diameter and myelination estimates in macaque and human brain.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Tensor-valued diffusion MRI detects brain microstructural abnormalities in HIV infected individuals with cognitive impairment.Scientific reports · 2024Article
- Menstrual cycle-driven hormone concentrations co-fluctuate with white and gray matter architecture changes across the whole brain.Human brain mapping · 2024Article
- Assessment of precision and accuracy of brain white matter microstructure using combined diffusion MRI and relaxometry.Human brain mapping · 2024Article
- Tensor-valued diffusion MRI detects brain microstructure changes in HIV infected individuals with cognitive impairment.Research square · 2024Article
- Insights and improvements in correspondence between axonal volume fraction measured with diffusion-weighted MRI and electron microscopy.NMR in biomedicine · 2024Article
- Article
- Variability of multidimensional diffusion-relaxation MRI estimates in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
21 more citing papers are in PubMed but not listed here.
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9 authors.
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Abstract
In vivo mapping of the neurite density with diffusion MRI (dMRI) is a high but challenging aim. First, it is unknown whether all neurites exhibit completely anisotropic ("stick-like") diffusion. Second, the "density" of tissue components may be confounded by non-diffusion properties such as T2 relaxation. Third, the domain of validity for the estimated parameters to serve as indices of neurite density is incompletely explored. We investigated these challenges by acquiring data with "b-tensor encoding" and multiple echo times in brain regions with low orientation coherence and in white matter lesions. Results showed that microscopic anisotropy from b-tensor data is associated with myelinated axons but not with dendrites. Furthermore, b-tensor data together with data acquired for multiple echo times showed that unbiased density estimates in white matter lesions require data-driven estimates of compartment-specific T2 values. Finally, the "stick" fractions of different biophysical models could generally not serve as neurite density indices across the healthy brain and white matter lesions, where outcomes of comparisons depended on the choice of constraints. In particular, constraining compartment-specific T2 values was ambiguous in the healthy brain and had a large impact on estimated values. In summary, estimating neurite density generally requires accounting for different diffusion and/or T2 properties between axons and dendrites. Constrained "index" parameters could be valid within limited domains that should be delineated by future studies.
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