ArticlePloS one2019
Longitudinal effects of aging on plasma proteins levels in older adults - associations with kidney function and hemoglobin levels.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Plasma Protein Profile of Incident Myocardial Infarction, Ischemic Stroke, and Heart Failure in 2 Cohorts.Journal of the American Heart Association · 2021Pooled it
- Genetic drivers of protein changes over time: Findings, considerations, and approaches in TOPMed cohorts and UK Biobank.bioRxiv : the preprint server for biology · 2026Article
- Plasma Proteomic Profiling of Young and Older Adults Identifies Candidate Biomarkers of Biological Aging at the Intersection of Age and Disease.Aging cell · 2026Article
- Article
- Exploring the impact of age, sex and life experiences on plasma inflammatory profiles through comparative proteomics.Frontiers in immunology · 2025Article
- Mapping biological influences on the human plasma proteome beyond the genome.Nature metabolism · 2024Article
- Measured and genetically predicted protein levels and cardiovascular diseases in UK Biobank and China Kadoorie Biobank.Nature cardiovascular research · 2024Article
- Epigenetic age acceleration and the risk of frailty, and persistent activities of daily living (ADL) disability.Age and ageing · 2024Article
- In vitro heterochronic parabiosis identifies pigment epithelium-derived factor as a systemic mediator of rejuvenation by young blood.bioRxiv : the preprint server for biology · 2024Article
- Association between Blood Parameters of Nutritional Status and Functional Status in Extreme Longevity.Nutrients · 2024Article
- Plasma Protein Profiling of Incident Cardiovascular Diseases: A Multisample Evaluation.Circulation. Genomic and precision medicine · 2023Article
- Proteomic profiling of longitudinal changes in kidney function among middle-aged and older men and women: the KORA S4/F4/FF4 study.BMC medicine · 2023Article
- Review
- Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence.Nature communications · 2022Article
- Progeria and Aging-Omics Based Comparative Analysis.Biomedicines · 2022Article
- Plasma Protein Levels Analysis in Multiple Sclerosis Sardinian Families Identified C9 and CYP24A1 as Candidate Biomarkers.Life (Basel, Switzerland) · 2022Article
- Review
- Article
- Assessing Genetic Overlap and Causality Between Blood Plasma Proteins and Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Can Serum Nitrosoproteome Predict Longevity of Aged Women?International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundA targeted proteomics chip has been shown to be useful to discover novel associations of proteins with cardiovascular disease. We investigated how these proteins change with aging, and whether this change is related to a decline in kidney function, or to a change in hemoglobin levels. MATERIAL AND
methodsIn the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, including 1,016 participants from the general population aged 70 at baseline, 84 proteins were measured at ages 70, 75, 80. At these occasions, glomerular filtration rate (eGFR) was estimated and the hemoglobin levels were measured.
resultsSixty-one of the 84 evaluated proteins changed significantly during the 10-year follow-up (multiple testing-adjusted alpha = 0.00059), most showing an increase. The change in eGFR was inversely related to changes of protein levels for the vast majority of proteins (74%). The change in hemoglobin was significantly related to the change in 40% of the evaluated proteins, with no obvious preference of the direction of these relationships.
conclusionThe majority of evaluated proteins increased with aging in adults. Therefore, normal ranges for proteins might be given in age-strata. The increase in protein levels was associated with the degree of reduction in eGFR for the majority of proteins, while no clear pattern was seen for the relationships between the proteins and the change in hemoglobin levels. Studies on changes in urinary proteins are warranted to understand the association between the reduction in eGFR and increase in plasma protein levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.