ArticlePloS one2019
Differentiation between blood and iodine in a bovine brain-Initial experience with Spectral Photon-Counting Computed Tomography (SPCCT).
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Differentiating Hemorrhage and Contrast Extravasation After Mechanical Thrombectomy Using Virtual Non-Contrast Photon-Counting CT.Clinical neuroradiology · 2026Article
- Advanced X-Ray Imaging Technology.Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer · 2026Review
- Advances in Ultrasmall Inorganic Nanoparticles for Nanomedicine: From Diagnosis to Therapeutics.ACS applied materials & interfaces · 2025Review
- Impact of patient habitus and acquisition protocol on iodine quantification in dual-source photon-counting computed tomography.Journal of medical imaging (Bellingham, Wash.) · 2024Article
- Incidence, Risk Factors, and Clinical Implications of Subarachnoid Hyperdensities on Flat-Panel Detector CT following Mechanical Thrombectomy in Patients with Anterior Circulation Acute Ischemic Stroke.AJNR. American journal of neuroradiology · 2024Article
- Dual Source Photon-Counting Computed Tomography-Part II: Clinical Overview of Neurovascular Applications.Journal of clinical medicine · 2023Review
- Article
- Spectral Photon-Counting CT Technology in Chest Imaging.Journal of clinical medicine · 2021Review
- Virtual non-calcium dual-energy CT: clinical applications.European radiology experimental · 2021Review
- Multicolor spectral photon counting CT monitors and quantifies therapeutic cells and their encapsulating scaffold in a model of brain damage.Nanotheranostics · 2020Article
- Feasibility of improving vascular imaging in the presence of metallic stents using spectral photon counting CT and K-edge imaging.Scientific reports · 2019Article
- Effect of Gold Nanoparticle Size on Their Properties as Contrast Agents for Computed Tomography.Scientific reports · 2019Article
- Hybrid Nano-GdFScientific reports · 2019Article
- Spectral Photon-Counting Computed Tomography (SPCCT): in-vivo single-acquisition multi-phase liver imaging with a dual contrast agent protocol.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the accuracy of Spectral Photon-Counting Computed Tomography (SPCCT) in the quantification of iodine concentrations and its potential for the differentiation between blood and iodine.
methodsTubes with blood and a concentration series of iodine were scanned with a preclinical SPCCT system (both in vitro and in an ex vivo bovine brain tissue sample). Iodine density maps (IDM) and virtual non-contrast (VNC) images were generated using the multi-bin spectral information to perform material decomposition. Region-of-interest (ROI) analysis was performed within the tubes to quantitatively determine the absolute content of iodine (mg/ml).
resultsIn conventional CT images, ROI analysis showed similar Hounsfield Unit (HU) values for the tubes with blood and iodine (59.9 ± 1.8 versus 59.2 ± 1.5). Iodine density maps enabled clear differentiation between blood and iodine in vitro, as well as in the bovine brain model. Quantitative measurements of the different iodine concentrations matched well with those of actual known concentrations even for very small iodine concentrations with values below 1mg/ml (RMSE = 0.19).
conclusionsSPCCT providing iodine maps and virtual non-contrast images allows material decomposition, differentiation between blood and iodine in vitro and ex vivo in a bovine brain model and reliably quantifies the iodine concentration.
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