ArticlePloS one2019
Evaluating trajectories of episodic memory in normal cognition and mild cognitive impairment: Results from ADNI.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 33 citations in OpenAlex.
- A Subtype Perspective on Cognitive Trajectories in Healthy Aging.Brain sciences · 2024Article
- Developmental Trajectories and Predictors of Incident Dementia among Elderly Taiwanese People: A 14-Year Longitudinal Study.International journal of environmental research and public health · 2023Article
- Subjective memory concerns, poor vascular health, and male sex predict exacerbated memory decline trajectories: An integrative data-driven class and prediction analysis.Neuropsychology · 2022Article
- MoCA 7.1: Multicenter Validation of the First Italian Version of Montreal Cognitive Assessment.Journal of Alzheimer's disease reports · 2022Article
- Validation and Normative Data of the Spanish Version of the Rey Auditory Verbal Learning Test and Associated Long-Term Forgetting Measures in Middle-Aged Adults.Frontiers in aging neuroscience · 2022Article
- Subjective Well-Being and Bilateral Anterior Insula Functional Connectivity After Exercise Intervention in Older Adults With Mild Cognitive Impairment.Frontiers in neuroscience · 2022Article
- Ambient Air Pollution and Long-Term Trajectories of Episodic Memory Decline among Older Women in the WHIMS-ECHO Cohort.Environmental health perspectives · 2021Article
- Textual Inference Comprehension in Mild Cognitive Impairment: The Influence of Semantic Processing and Verbal Episodic Memory.Frontiers in aging neuroscience · 2021Article
- Exercise Training-Related Changes in Cortical Gray Matter Diffusivity and Cognitive Function in Mild Cognitive Impairment and Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
- Trajectories of cognitive function in community-dwelling older adults: A longitudinal study of population heterogeneity.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Four Common Late-Life Cognitive Trajectories Patterns Associate with Replicable Underlying Neuropathologies.Journal of Alzheimer's disease : JAD · 2021Article
- Distinct Cognitive Trajectories in Late Life and Associated Predictors and Outcomes: A Systematic Review.Journal of Alzheimer's disease reports · 2020Review
- [Application of semantic segmentation based on convolutional neural network in medical images].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Review
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6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundMemory assessment is a key factor for the diagnosis of cognitive impairment. However, memory performance over time may be quite heterogeneous within diagnostic groups.
methodTo identify latent trajectories in memory performance and their associated risk factors, we analyzed data from Alzheimer's Disease Neuroimaging Initiative (ADNI) participants who were classified either as cognitively normal or as Mild Cognitive Impairment (MCI) at baseline and were administered the Rey Auditory Verbal Learning test (RAVLT) for up to 9 years. Group-based trajectory modeling on the 30-minute RAVLT delayed recall score was applied separately to the two baseline diagnostic groups.
resultsThere were 219 normal subjects with mean age 75.9 (range from 59.9 to 89.6) and 52.5% male participants, and 372 MCI subjects with mean age 74.8 (range from 55.1 to 89.3) and 63.7% male participants included in the analysis. For normal subjects, six trajectories were identified. Trajectories were classified into three types, determined by the shape, each of which may comprise more than one trajectory: stable (~30% of subjects), curvilinear decline (~ 28%), and linear decline (~ 42%). Notably, none of the normal subjects assigned to the stable stratum progressed to dementia during the study period. In contrast, all trajectories identified for the MCI group tended to decline, although some participants were later re-diagnosed with normal cognition. Age, sex, and education were significantly associated with trajectory membership for both diagnostic groups, while APOE ɛ4 was only significantly associated with trajectories among MCI participants.
conclusionMemory trajectory is a strong indicator of dementia risk. If likely trajectory of memory performance can be identified early, such work may allow clinicians to monitor or predict progression of individual patient cognition. This work also shows the importance of longitudinal cognitive testing and monitoring.
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