ArticlePLoS neglected tropical diseases2019
Implementation of a practical and effective pilot intervention against transmission of Taenia solium by pigs in the Banke district of Nepal.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Neurocysticercosis control for primary epilepsy prevention: a systematic review.Pathogens and global health · 2022Pooled it
- Evaluation of a One Health public health program based on minimum inputs to control Taenia solium in Madagascar.PLoS neglected tropical diseases · 2025Article
- Age at infection as a key predictor of cyst burden in pigs experimentally infected with Taenia solium.Parasites & vectors · 2025Article
- Prevalence of Cysticercosis in Pigs and Risk Assessment Among Occupationally Exposed Workers in Benue State, Nigeria.Veterinary medicine and science · 2025Article
- The Frequency of Porcine Cysticercosis and Factors Associated withPathogens (Basel, Switzerland) · 2024Article
- Insights into the diagnosis, vaccines, and control of Taenia solium, a zoonotic, neglected parasite.Parasites & vectors · 2023Review
- Aggregation ofParasite epidemiology and control · 2023Review
- Control trial of porcine cysticercosis in Uganda using a combination of the TSOL18 vaccination and oxfendazole.Infectious diseases of poverty · 2021Article
- Demand forFrontiers in veterinary science · 2021Article
- Socio-economic and health costs of porcine/human cysticercosis, neurocysticercosis and epilepsy to small-scale pig producers in Tanzania.Bulletin of the National Research Centre · 2021Review
- Force-of-infection of Taenia solium porcine cysticercosis: a modelling analysis to assess global incidence and prevalence trends.Scientific reports · 2020Article
- Mimotope-based antigens as potential vaccine candidates in experimental murine cysticercosis.Parasitology · 2020Article
- TSOL18 vaccine and oxfendazole for control of Taenia solium cysticercosis in pigs: A field trial in endemic areas of Tanzania.PLoS neglected tropical diseases · 2020Article
- Taenia solium Cysticercosis and Its Impact in Neurological Disease.Clinical microbiology reviews · 2020Review
- Use of Veterinary Vaccines for Livestock as a Strategy to Control Foodborne Parasitic Diseases.Frontiers in cellular and infection microbiology · 2020Review
- Accurate diagnosis of lesions suspected of being caused by Taenia solium in body organs of pigs with naturally acquired porcine cysticercosis.PLoS neglected tropical diseases · 2019Article
- Control ofFrontiers in veterinary science · 2019Article
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Taenia solium is a zoonotic cestode parasite which causes human neurocysticercosis. Pigs transmit the parasite by acting as the intermediate host. An intervention was implemented to control transmission of T. solium by pigs in Dalit communities of Banke District, Nepal. Every 3 months, pigs were vaccinated with the TSOL18 recombinant vaccine (Cysvax, IIL, India)) and, at the same time, given an oral treatment with 30mg/kg oxfendazole (Paranthic 10% MCI, Morocco). The prevalence of porcine cysticercosis was determined in both an intervention area as well as a similar no intervention control area, among randomly selected, slaughter-age pigs. Post mortem assessments were undertaken both at the start and at the end of the intervention. Participants conducting the post mortem assessments were blinded as to the source of the animals being assessed. At the start of the intervention the prevalence of porcine cysticercosis was 23.6% and 34.5% in the control and intervention areas, respectively. Following the intervention, the prevalence of cysticercosis in pigs from the control area was 16.7% (no significant change), whereas no infection was detected after complete slicing of all muscle tissue and brain in animals from the intervention area (P = 0.004). These findings are discussed in relation to the feasibility and sustainability of T. solium control. The 3-monthly vaccination and drug treatment intervention in pigs used here is suggested as an effective and practical method for reducing T. solium transmission by pigs. The results suggest that applying the intervention over a period of years may ultimately reduce the number of tapeworm carriers and thereby the incidence of NCC.
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