Evidence map›Paper›PMID 30801996›Full record

ArticleCurrent protocols in mouse biology2019

Use of Isotope Tracers to Assess Lipid Absorption in Conscious Lymph Fistula Mice.

Chih-Wei Ko, Jie Qu, Min Liu, Dennis D Black, Patrick Tso

Abstract read
In one paragraph

Article in Current protocols in mouse biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Transport functions of intestinal lymphatic vessels.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chih-Wei KoDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.
Jie QuDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.
Min LiuDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.
Dennis D BlackChildren's Foundation Research Institute at Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee.
Patrick TsoDepartment of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio.
University of Cincinnati · USUniversity of Tennessee Health Science Center · US

Funding

LIPID, LIPOPROTEIN, AND GLUCOSE METABOLISM COREU24DK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2001 to 2015
$12.9M
Lipid profile, lipoprotein and apolipoprotein composition, and intestinal fat absorption efficiency in germ-free and conventional miceU2CDK059630 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN · 2016 to 2021
$4.9M
Role of the GI lymphatic system in hormonal signaling and nutrient metabolismR01DK119135 · NIDDK · UNIVERSITY OF CINCINNATI · PI LIU, MIN, TSO, PATRICK · 2018 to 2022
$3.0M
Apolipoprotein AV and intestinal transportR01DK103557 · NIDDK · UNIVERSITY OF CINCINNATI · PI TSO, PATRICK · 2015 to 2019
$1.9M
INTESTINAL LIPOPROTEINS IN THE NEONATER01HD022551 · NICHD · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI BLACK, DENNIS DARREL · 1994 to 2007
$1.8M
NICHD NIH HHS R01 HD022551NIDDK NIH HHS R01 DK103557NIDDK NIH HHS R01 DK119135NIDDK NIH HHS U24 DK059630NIDDK NIH HHS U2C DK059630NIH HHS DK103557NIH HHS DK119135NIH HHS DK59630NIH HHS HD22551
6 · The paper itself

Abstract

This protocol provides a comprehensive reference for the evolution of the lymph fistula model, the mechanism of lipid absorption, the detailed procedure for studying lipid absorption using the lymph fistula model, the interpretation of the results, and consideration of the experimental design. The lymph fistula model is an approach to assess the concentration and rate of a range of molecules transported by the lymph by cannulating lymph duct in animals. In this protocol, mice first undergo surgery with the implantation of cannulae in the duodenum and mesenteric lymph duct and are allowed to recover overnight in Bollman restraining cages housed in a temperature-regulated environment. To study in vivo lipid absorption, a lipid emulsion is prepared with labeled tracers, including [

Indexed as

Lipid MetabolismAnimalsCarbon RadioisotopesCholesterolLymphLymphatic SystemMiceTrioleinTritiumCarbon-14Carbon RadioisotopesCholesterolTrioleinTritiumgastrointestinal tractintestinal lymph ductlipid absorptionlymph fistula

Identifiers

PMID30801996
PMCPMC6401309
OpenAlexW2917654745

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.