ArticleAging cell2019
Genetically heterogeneous mice exhibit a female survival advantage that is age- and site-specific: Results from a large multi-site study.
Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Selective Breeding for Voluntary Wheel-Running Behavior in Mice is not Associated with Reduced Lifetime Reproductive Success or Lifespan Under Long-Term Paired Breeding Conditions.Behavior genetics · 2026Article
- The association of frailty with age and lifespan in mice differs by strain and sex.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Article
- Aging-associated autoimmunity in genetically diverse UM-HET3 mice shows an early female sex bias.GeroScience · 2026Article
- Deciphering the timing and impact of life-extending interventions: temporal efficacy profiler distinguishes early, midlife, and senescence phase efficacies.Nature communications · 2025Article
- Genetic regulation of fasting-induced longevity effects.bioRxiv : the preprint server for biology · 2025Article
- Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci.Genetics · 2025Article
- Sex as a major determinant of pro-longevity drug efficacy: a review of two decades of the NIA Interventions Testing Program.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Review
- Article
- Aging activates escape of the silent X chromosome in the female mouse hippocampus.Science advances · 2025Article
- Biological sex matters in brain aging.Neuron · 2025Review
- Computational and digital analyses in the INSPIRE mouse cohort to define sex-specific functional determinants of biological aging.Science advances · 2024Article
- Review
- Quantifying the Impact of Co-Housing on Murine Aging Studies.bioRxiv : the preprint server for biology · 2024Article
- Dynamics of single-nuclei transcriptomic profiling of adipose tissue from diverse anatomical locations during mouse aging process.Scientific reports · 2024Article
- Early Life Interventions: Impact on Aging and Longevity.Aging and disease · 2024Review
- Article
- Article
- Prepubertal castration eliminates sex differences in lifespan and growth trajectories in genetically heterogeneous mice.Aging cell · 2023Article
- The Stria Vascularis in Mice and Humans Is an Early Site of Age-Related Cochlear Degeneration, Macrophage Dysfunction, and Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The female survival advantage is a robust characteristic of human longevity. However, underlying mechanisms are not understood, and rodent models exhibiting a female advantage are lacking. Here, we report that the genetically heterogeneous (UM-HET3) mice used by the National Institute on Aging Interventions Testing Program (ITP) are such a model. Analysis of age-specific survival of 3,690 control ITP mice revealed a female survival advantage paralleling that of humans. As in humans, the female advantage in mice was greatest in early adulthood, peaking around 350 days of age and diminishing progressively thereafter. This persistent finding was observed at three geographically distinct sites and in six separate cohorts over a 10-year period. Because males weigh more than females and bodyweight is often inversely related to lifespan, we examined sex differences in the relationship between bodyweight and survival. Although present in both sexes, the inverse relationship between bodyweight and longevity was much stronger in males, indicating that male mortality is more influenced by bodyweight than is female mortality. In addition, male survival varied more across site and cohort than female survival, suggesting greater resistance of females to environmental modulators of survival. Notably, at 24 months the relationship between bodyweight and longevity shifted from negative to positive in both sexes, similar to the human condition in advanced age. These results indicate that the UM-HET3 mouse models the human female survival advantage and provide evidence for greater resilience of females to modulators of survival.
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