Observational studyJournal of magnetic resonance imaging : JMRI2019
Comparing invasive with MRI-derived intracranial pressure measurements in healthy elderly and brain trauma cases: A pilot study.
Observational study in Journal of magnetic resonance imaging : JMRI, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- A mathematical model for predicting intracranial pressure based on noninvasively acquired PC-MRI parameters in communicating hydrocephalus.Journal of clinical monitoring and computing · 2021Trial
- Article
- Ophthalmologic assessment and intracranial pressure in children: diagnostic methods, clinical correlations, and future directions.Frontiers in pediatrics · 2026Review
- Prediction of Cerebrospinal Fluid (CSF) Pressure with Generative Adversarial Network Synthetic Plasma-CSF Biomarker Pairing.Neuroinformatics · 2025Article
- Non-invasive assessment of intracranial compliance in idiopathic intracranial hypertension: an MRI-ICP study.Eye (London, England) · 2025Article
- Optical coherence tomography surpasses fundus imaging and intracranial pressure measurement in monitoring idiopathic intracranial hypertension.Scientific reports · 2025Article
- Noninvasive intracranial pressure profile in 31 patients submitted to fullendoscopic spine surgery.Acta cirurgica brasileira · 2024Article
- Intracranial pressure monitoring in neurosurgery: the present situation and prospects.Chinese neurosurgical journal · 2023Review
- Is Lumbar Puncture Needed? - Noninvasive Assessment of ICP Facilitates Decision Making in Patients with Suspected Idiopathic Intracranial Hypertension.Ultraschall in der Medizin (Stuttgart, Germany : 1980) · 2023Article
- Non-Invasive Intracranial Pressure Monitoring.Journal of clinical medicine · 2023Review
- Non-invasive detection of intracranial pressure related to the optic nerve.Quantitative imaging in medicine and surgery · 2021Review
- Extracranial versus intracranial hydro-hemodynamics during aging: a PC-MRI pilot cross-sectional study.Fluids and barriers of the CNS · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundIntracranial pressure (ICP) is an important physiological parameter in several neurological disorders. Considerable effort has been made to measure ICP noninvasively. MR-based ICP (MR-ICP) is a nonempirical method based on principles of cerebrospinal fluid (CSF) physiology, where ICP is obtained from measurements of blood and CSF flows to and from the cranium during the cardiac cycle. PURPOSE: To compare MR-ICP with invasive ICP measurements obtained using lumbar puncture (LP) or external ventricular drainage (EVD). STUDY TYPE: Prospective, cross-sectional, observational study. SUBJECTS: Ten cognitively healthy elderly subjects (age 69.6 ± 6.6 years; seven females) and six brain trauma patients (age 36.8 ± 19.7 years; two females). FIELD STRENGTH: Velocity encoding cine phase-contrast at 1.5 T and 3 T. ASSESSMENT: MR-ICP and craniospinal compliance distribution were estimated from arterial inflow and venous outflow to and from cranium, and craniospinal CSF flow at the upper cervical region, measured using cine phase contrast MRI. LP (done 177 ± 163 days after scan) and EVD measurements (at the time of scan) were performed in lateral recumbent and supine positions, respectively. STATISTICAL TESTS: Linear regression was used to assess the relationships of MR-ICP with invasive ICP, and the dependency of these measurements on age, weight, height, and BMI. A Shapiro-Wilks test and Bland-Altman plot were respectively used to evaluate the normality and agreement between these two pressure distributions. Student's t-test was used throughout the analysis to compare differences between the EVD and LP cohorts.
resultsIn the combined cohort, MR-ICP and invasive ICP were positively correlated (r = 0.95, P < 0.001), with invasive ICP being higher than MR-ICP by 2.2 mmHg on average. In the healthy cohort, the cranial contribution to total craniospinal compliance was negatively correlated with MR-ICP (r = -0.90, P < 0.001). DATA
conclusionMR-ICP provides a reliable estimate of ICP, with 14 out of 16 datapoints within the clinically acceptable error. Craniospinal compliance distribution plays a role in modulating ICP in supine position. LEVEL OF EVIDENCE: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:975-981.
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