Evidence map›Paper›PMID 30801848›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2019

Genetic interactions between Ror2 and Wnt9a, Ror1 and Wnt9a and Ror2 and Ror1: Phenotypic analysis of the limb skeleton and palate in compound mutants.

Martina Weissenböck, Richard Latham, Michiru Nishita, Lena Ingeborg Wolff, Hsin-Yi Henry Ho, Yasuhiro Minami, Christine Hartmann

Open access · bronzeAbstract read
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Role of the Ror family receptors in Wnt5a signaling.In vitro cellular & developmental biology. Animal · 2024
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Obstetrical Challenges in Robinow Syndrome.Case reports in obstetrics and gynecology · 2022
    Article
  10. Article
  11. Heterozygous Recurrent Mutations Inducing Dysfunction ofFrontiers in cell and developmental biology · 2021
    Article
  12. Article
  13. Review
  14. WNT9A and WNT9B in Development and Disease.Differentiation; research in biological diversity
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 4 countries.

Martina WeissenböckResearch Institute of Molecular Pathology, Vienna, Austria.
Richard LathamResearch Institute of Molecular Pathology, Vienna, Austria.
Michiru NishitaDivision of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan.
Lena Ingeborg WolffDepartment of Bone and Skeletal Research, Medical Faculty, Institute of Musculoskeletal Medicine, University of Münster, Münster, Germany.
Hsin-Yi Henry HoDepartment of Cell Biology and Human Anatomy, University of California Davis School of Medicine, Davis, California.
Yasuhiro MinamiDivision of Cell Physiology, Department of Physiology and Cell Biology, Graduate School of Medicine, Kobe University, Kobe, Japan.ORCID https://orcid.org/0000-0003-3514-4285
Christine HartmannDepartment of Bone and Skeletal Research, Medical Faculty, Institute of Musculoskeletal Medicine, University of Münster, Münster, Germany.ORCID https://orcid.org/0000-0002-6854-8633
Kobe University · JPResearch Institute of Molecular Pathology · ATUniversity of Münster · DEUniversity of California, Davis · US

Funding

Deciphering Wnt-Ror signaling in cytoskeletal regulation and tissue shape controlR35GM119574 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HO, HSIN-YI HENRY · 2016 to 2021
$2.0M
Boehringer IngelheimGerman Federal Ministry of Education and Science 01EC1408ENational Institutes of Health 1R35GM119574NIGMS NIH HHS R35 GM119574
6 · The paper itself

Abstract

Mutations in the human receptor tyrosine kinase ROR2 are associated with Robinow syndrome (RRS) and brachydactyly type B1. Amongst others, the shortened limb phenotype associated with RRS is recapitulated in Ror2

Indexed as

Epistasis, GeneticMutationAnimalsCleft PalateLimb Deformities, CongenitalMiceMice, Inbred C57BLOsteogenesisPhenotypeReceptor Tyrosine Kinase-like Orphan ReceptorsWnt ProteinsReceptor Tyrosine Kinase-like Orphan ReceptorsRor1 protein, mouseRor2 protein, mouseWnt9a protein, mouseWnt Proteinschondrogenesisendochondral ossificationlimb skeletonRor1Ror2secondary cleft palateWnt9a

Identifiers

PMID30801848
PMCPMC7340625
OpenAlexW2916174643

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.