ArticleJournal of hypertension2019
Central systolic pressure and a nonessential amino acid metabolomics profile: the African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension.
Article in Journal of hypertension, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 40 citations in OpenAlex.
- Searching for Metabolic Markers for Hypertension in Human Urine.Molecules (Basel, Switzerland) · 2026Article
- Identification of Blood Pressure-Associated Metabolites by Integrating Metabolomic and Genetic Analysis.MedComm · 2026Article
- Metabolomics and Precision Medicine in Resistant Hypertension: Pathophysiological Insights, Biomarker Discovery, and Translational Strategies.International journal of hypertension · 2026Review
- Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum.Molecules (Basel, Switzerland) · 2025Article
- Metabolomics for Distinguishing Cardiovascular Risk in Rheumatoid Arthritis Across Different Disease-Modifying Antirheumatic Drug Therapies.Journal of clinical medicine research · 2025Article
- Urinary metabolomics signature of animal and plant protein intake and its association with 24-h blood pressure: the African-PREDICT study.Hypertension research : official journal of the Japanese Society of Hypertension · 2024Article
- Exploring the interplay between kidney function and urinary metabolites in young adults: the African-PREDICT study.Amino acids · 2024Article
- Homocysteine, blood pressure and gene-diet interactions in relation to vascular function measures of black South Africans.Genes & nutrition · 2024Article
- The Africa non-communicable diseases (NCD) Open Lab: Impact of a portfolio of clinical studies to deepen the understanding of NCDs in sub-Saharan Africa.Journal of global health · 2024Article
- Unraveling the gut microbiota's role in salt-sensitive hypertension: current evidences and future directions.Frontiers in cardiovascular medicine · 2024Review
- ProbioticsmSystems · 2023Article
- Urinary Peptidomics and Pulse Wave Velocity: The African-PREDICT Study.Journal of proteome research · 2023Article
- Early vascular ageing phenotypes and urinary targeted metabolomics in children and young adults: the ExAMIN Youth SA and African-PREDICT studies.Amino acids · 2023Article
- Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study.Metabolomics : Official journal of the Metabolomic Society · 2023Article
- Association of Plasma Metabolites and Salt Sensitivity of Blood Pressure in Chinese Population: The EpiSS StudyNutrients · 2023Article
- Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies.Hypertension research : official journal of the Japanese Society of Hypertension · 2022Article
- Serum metabolites of hypertension among Chinese adolescents aged 12-17 years.Journal of human hypertension · 2022Article
- Influence of Genetic West African Ancestry on Metabolomics among Hypertensive Patients.Metabolites · 2022Article
- Preanalytical Pitfalls in Untargeted Plasma Nuclear Magnetic Resonance Metabolomics of Endocrine Hypertension.Metabolites · 2022Article
- Metabolomics study of blood pressure salt-sensitivity and hypertension.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2022Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
objectivesEarly-life exposures to cardiovascular risk factors may manifest as early vascular ageing, a phenomenon to which black populations are more prone. The metabolome provides insight into the current state and regulation of physiological processes and was used to investigate the early molecular determinants of arterial stiffness.
methodsBlack (N = 80) and white (N = 80) men and women (aged 20-30 years, clinic blood pressure <140 and 90 mmHg) across the arterial stiffness spectrum were included. Carotid-femoral pulse wave velocity, central SBP (cSBP) and central pulse pressure (cPP) were measured. NMR spectroscopy, liquid chromatography tandem mass spectrometry and gas chromatography-time of flight-mass spectrometry methods produced metabolomic data.
resultsDifferences (d ≥ 0.3) in 34 metabolites between black and white groups were found (adjusted for multiple comparisons). Only cSBP were higher in the black group (P = 0.003). Lower dietary protein intake (P < 0.001), but higher urinary nonessential amino acid levels were found in the black group (q ≤ 0.05). In multivariable-adjusted regression models cSBP and cPP inversely correlated with various nonessential amino acids, but only in black adults. These include associations of cSBP with 4-hydroxyproline (β = -0.24; P = 0.042), alanine: (β = -0.29; P = 0.015), glutamine (β = -0.25; P = 0.028), glycine (β = -0.26; P = 0.027), histidine (β = -0.30; P = 0.009), serine (β = -0.29; P = 0.012), and associations of cPP with alanine (β = -0.31; P = 0.005) and serine (β = -0.26; P = 0.019).
conclusionThese amino acids play pivotal roles in collagen metabolism, glucose metabolism and oxidative stress and this ethnic-specific finding suggests that biosynthesis of nonessential amino acids may be upregulated to protect the vasculature against the onset of early vascular deterioration.
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