Evidence map›Paper›PMID 30801250›Full record

ArticleeLife2019

Aurora A depletion reveals centrosome-independent polarization mechanism in

Kerstin Klinkert, Nicolas Levernier, Peter Gross, Christian Gentili, Lukas von Tobel, Marie Pierron, Coralie Busso, Sarah Herrman, Stephan W Grill, Karsten Kruse and 1 more

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Internal feedback circuits among MEX-5, MEX-6, and PLK-1 maintain faithful patterning in theProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Cellular and molecular mechanisms of asymmetric stem cell division in tissue homeostasis.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Review
  10. Article
  11. PLK-1 regulates MEX-1 polarization in thebioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Origin and development of primary animal epithelia.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024
    Review
  15. Article
  16. Article
  17. Temporally distinct roles of Aurora A in polarization of thebioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kerstin KlinkertSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0001-5268-3710
Nicolas LevernierDepartment of Biochemistry, University of Geneva, Geneva, Switzerland.
Peter GrossBIOTEC, TU Dresden, Dresden, Germany.
Christian GentiliSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Lukas von TobelSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Marie PierronSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Coralie BussoSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Sarah HerrmanSwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.
Stephan W GrillBIOTEC, TU Dresden, Dresden, Germany.
Karsten KruseDepartment of Biochemistry, University of Geneva, Geneva, Switzerland.
Pierre GönczySwiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology Lausanne (EPFL), Lausanne, Switzerland.ORCID 0000-0002-6305-6883

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
European Research Council 281903NIH HHS P40 OD010440Swiss National Science Foundation 205321_175996Swiss National Science Foundation 31003A_155942
6 · The paper itself

Abstract

How living systems break symmetry in an organized manner is a fundamental question in biology. In wild-type

Indexed as

Body PatterningAnimalsAurora Kinase ACaenorhabditis elegansCaenorhabditis elegans ProteinsCentrosomeZygoteair-1 protein, C elegansAurora Kinase ACaenorhabditis elegans Proteinsanterior-posterior polarityAurora AC. eleganscell biologyphysical analysissymmetry breaking

Identifiers

PMID30801250
PMCPMC6417861

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.