ArticleeLife2019
Discriminative stimuli are sufficient for incubation of cocaine craving.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Sex Differences in Opioid and Psychostimulant Craving and Relapse: A Critical Review.Pharmacological reviews · 2022Pooled it
- Neuronal Grin2c expression and the cocaine engram: a medial prefrontal cortex substrate for conditioned place preference.bioRxiv : the preprint server for biology · 2026Article
- Persistent vulnerability to heroin relapse after more than one year of abstinence in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Persistent vulnerability to heroin relapse across the adult lifespan in rats.bioRxiv : the preprint server for biology · 2026Article
- Medial prefrontal cortical neurotransmitters reactive to relapse-promoting and relapse-suppressing cues in male rats trained to self-administer cocaine or alcohol.Addiction neuroscience · 2026Article
- Activation of infralimbic cortex neurons projecting to the nucleus accumbens shell suppresses discriminative stimulus-triggered relapse to cocaine seeking in rats.Psychopharmacology · 2025Article
- Biomolecular correlates of incubated sucrose-seeking within ventromedial prefrontal cortex are sex- and subregion-selective.Pharmacology, biochemistry, and behavior · 2025Article
- Distinct prelimbic cortex ensembles encode response execution and inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Activating group II metabotropic glutamate receptors in the basolateral amygdala inhibits increases in reward seeking triggered by discriminative stimuli in rats.The international journal of neuropsychopharmacology · 2025Article
- Operant social seeking to a novel peer after social isolation is associated with activation of nucleus accumbens shell in rats.Psychopharmacology · 2025Article
- Neurobiology of the incubation of drug craving: An update.Pharmacological reviews · 2025Review
- Delineating anticipatory arousal from reward consumption: evaluating fixed-intervals in cocaine seeking-taking response chains.Psychopharmacology · 2025Article
- Sex differences in stress-modulated cocaine vulnerability: female rodents are more sensitive to the effects of stress exposure at different developmental stages.Frontiers in behavioral neuroscience · 2025Review
- Relapse after electric barrier-induced voluntary abstinence: A review.Current opinion in neurobiology · 2024Review
- Article
- Incubation of palatable food craving is associated with brain-wide neuronal activation in mice.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Investigating discriminative stimulus modulation of opioid seeking after conflict-induced abstinence in sign- and goal-tracking rats.Psychopharmacology · 2022Article
- Contextual extinction of drug-associated discriminative stimuli fails to attenuate drug-vs-food choice in rhesus monkeys.Journal of the experimental analysis of behavior · 2022Article
- Sex differences in sucrose reinforcement in Long-Evans rats.Biology of sex differences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Rajtarun MadangopalNeuronal Ensembles in Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.ORCID 0000-0001-6202-302X
Brendan J TunstallNeurobiology of Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Lauren E KomerNeuronal Ensembles in Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Sophia J WeberNeuronal Ensembles in Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Jennifer K HootsNeurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Veronica A LennonNeuronal Ensembles in Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Jennifer M BossertNeurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
David H EpsteinReal-world Assessment, Prediction, and Treatment Unit, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Yavin ShahamNeurobiology of Relapse Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.
Bruce T HopeNeuronal Ensembles in Addiction Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, United States.ORCID 0000-0001-5804-7061
National Institutes of Health · US
Funding
Neurobiology Of Relapse To Opiate and Psychostimulant DrugsZIADA000434 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI SHAHAM, YAVIN · 2009 to 2025
$39.8MCharacterization of neuronal ensembles activated during drug-induced behaviorZIADA000467 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HOPE, BRUCE · 2009 to 2025
$35.8MSensitized Neurons that Mediate Sensitized BehaviorZ01DA000467 · NIDA · NATIONAL INSTITUTE ON DRUG ABUSE · PI HOPE, BRUCE · 2004 to 2008
$1.7MDEPRESSION PRONE SMOKERS AND CIGARETTE CRAVINGK08DA000467 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MCCHARGUE, DENNIS E · 2000 to 2004
$535kIntramural NIH HHS Z01 DA000467NIDA NIH HHS DA000467-15NIDA NIH HHS K08 DA000467
Abstract
In abstinent drug addicts, cues formerly associated with drug-taking experiences gain relapse-inducing potency ('
Indexed as
CravingAnimalsCocaineDisease Models, AnimalRatsRecurrenceSecondary PreventionSubstance-Related DisordersCocaineabstinenceaddictioncocainedrug cuedrug-seekingfoodneurosciencerat
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC0
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.