ArticleeLife2019
Chronology-based architecture of descending circuits that underlie the development of locomotor repertoire after birth.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 87 citations in OpenAlex.
- CLOK: a chemigenetic multicolor labeling system to visualize neuronal birthdate and circuit integration.Nature neuroscience · 2026Article
- Genetic structure and selective signatures revealed by whole genome sequencing in potato grouper (Epinephelus tukula).BMC genomics · 2026Article
- Distinct developmental dynamics of opposing persistent currents shape motoneuron firing during motor maturation of zebrafish.The Journal of physiology · 2026Article
- Whole-body central processing of lateral line inputs encodes flow direction relative to the center-of-mass.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Birthdate aligns vestibular sensory neurons with central and motor partners across a sensorimotor reflex circuit for gaze stabilization.Development (Cambridge, England) · 2026Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.eLife · 2025Article
- Supraspinal commands have a modular organization that is behavioral context specific.Current biology : CB · 2025Article
- Construction of a Core Germplasm and Identification of Candidate SNPs Associated with Growth Performance of Epinephelus tukula by Whole-Genome Resequencing.Marine biotechnology (New York, N.Y.) · 2025Article
- Separate brainstem circuits for fast steering and slow exploratory turns.Nature communications · 2025Article
- Coordinated spinal locomotor network dynamics emerge from cell-type-specific connectivity patterns.bioRxiv : the preprint server for biology · 2025Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.eLife · 2024Article
- The Vestibulospinal Nucleus Is a Locus of Balance Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The vestibulospinal nucleus is a locus of balance development.bioRxiv : the preprint server for biology · 2024Article
- Dimensionality of locomotor behaviors in developing C. elegans.PLoS computational biology · 2024Article
- Motor neurons are dispensable for the assembly of a sensorimotor circuit for gaze stabilization.bioRxiv : the preprint server for biology · 2024Article
- Multisensory navigational strategies of hatchling fish for dispersal.Current biology : CB · 2023Article
- The mesencephalic locomotor region recruits V2a reticulospinal neurons to drive forward locomotion in larval zebrafish.Nature neuroscience · 2023Article
- Article
- Cerebrospinal fluid-contacting neurons: multimodal cells with diverse roles in the CNS.Nature reviews. Neuroscience · 2023Review
- Spinal Interneurons: Diversity and Connectivity in Motor Control.Annual review of neuroscience · 2023Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of new and increasingly sophisticated behaviors after birth is accompanied by dramatic increase of newly established synaptic connections in the nervous system. Little is known, however, of how nascent connections are organized to support such new behaviors alongside existing ones. To understand this, in the larval zebrafish we examined the development of spinal pathways from hindbrain V2a neurons and the role of these pathways in the development of locomotion. We found that new projections are continually layered laterally to existing neuropil, and give rise to distinct pathways that function in parallel to existing pathways. Across these chronologically layered pathways, the connectivity patterns and biophysical properties vary systematically to support a behavioral repertoire with a wide range of kinematics and dynamics. Such layering of new parallel circuits equipped with systematically changing properties may be central to the postnatal diversification and increasing sophistication of an animal's behavioral repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.