Evidence map›Paper›PMID 30800698›Full record

ArticleOpen forum infectious diseases2019

Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016-2017.

Marie E Killerby, Faye Rozwadowski, Xiaoyan Lu, Mardea Caulcrick-Grimes, Lisa McHugh, Ann Marie Haldeman, Tara Fulton, Eileen Schneider, Senthilkumar K Sakthivel, Julu Bhatnagar and 4 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  12. Human Adenovirus 7-Associated Hemophagocytic Lymphohistiocytosis-like Illness: Clinical and Virological Characteristics in a Cluster of Five Pediatric Cases.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  13. Review
  14. Outbreaks of Adenovirus-associated Respiratory Illness on 5 College Campuses in the United States, 2018-2019.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  15. Article
  16. Article
  17. Cross-infection of adenovirus among medical staff: A warning from the intensive care unit in a tertiary care teaching hospital in China.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marie E KillerbyRespiratory Viruses Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Faye RozwadowskiEpidemic Intelligence Service, Division of Scientific Education and Professional Development.
Xiaoyan LuRespiratory Viruses Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Mardea Caulcrick-GrimesNew Jersey Department of Health, Trenton.
Lisa McHughNew Jersey Department of Health, Trenton.
Ann Marie HaldemanNew Jersey Department of Health, Trenton.
Tara FultonNew Jersey Department of Health, Trenton.
Eileen SchneiderRespiratory Viruses Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Senthilkumar K SakthivelRespiratory Viruses Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
Julu BhatnagarInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Demi B RabeneckInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Sherif ZakiInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
Susan I GerberRespiratory Viruses Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.
John T WatsonRespiratory Viruses Branch, Division of Viral Diseases, National Center for Immunization and Respiratory Diseases.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman adenoviruses (HAdVs) are known causes of respiratory illness outbreaks in congregate settings, but cases and clusters are less well described from community settings in the United States. During December 2016-February 2017, the New Jersey Department of Health received reports of HAdV infections from 3 sources in 3 adjacent counties. We investigated to characterize the epidemiologic, laboratory, and clinical features of this HAdV outbreak.

methodsA case was defined as a New Jersey resident with acute respiratory illness during December 1, 2016-March 31, 2017 with laboratory identification of HAdV genome type 7d (HAdV-7d). Human adenovirus was detected by real-time and conventional polymerase chain reaction and molecular typed by partial hexon capsid protein gene sequencing. The HAdV genome type was identified by whole genome sequencing analysis. Available medical, public health, and surveillance records were reviewed.

resultsWe identified 12 cases, including 3 treatment facility patients, 7 college students, and 2 cases at a tertiary-care hospital. Four cases died; all had underlying comorbidities. Nine HAdV-7d whole genome sequences obtained from all 3 sites were nearly identical.

conclusionsTransmission of HAdV-7d occurred in community and congregate settings across 3 counties and resulted in severe morbidity and mortality in some cases with underlying comorbidities. Clinicians and local and state health departments should consider HAdV in patients with severe respiratory infection.

Indexed as

acute respiratory diseasehuman adenovirusoutbreakrespiratory virus

Identifiers

PMID30800698
PMCPMC6379021

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.