ArticleBioMed research international2019
Amino Acid Biosignature in Plasma among Ischemic Stroke Subtypes.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.
- Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence.Frontiers in neurology · 2025Pooled it
- Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Dual-mode analysis of ischemic stroke based on urine SERS spectra and carotid B-ultrasound.Science advances · 2026Article
- Early Metabolic Alterations Are Associated with Intraventricular Hemorrhage and Its Complications in Very Preterm Infants.Neonatology · 2026Article
- Structural basis for the transport mechanism and cholesterol modulation of the human proline transporter.Nature communications · 2026Article
- Plasma Cystine as a Marker of Acute Stroke Severity.Diagnostics (Basel, Switzerland) · 2025Article
- Dietary Amino Acids and Risk of Stroke Subtypes: Results from 3 Large Prospective Cohort Studies.The Journal of nutrition · 2025Article
- Metabolomic discoveries for early diagnosis and traditional Chinese medicine efficacy in ischemic stroke.Biomarker research · 2024Review
- Association of metabolites on ischemic stroke subtypes: a 2-sample Mendelian randomization study.Frontiers in neurology · 2024Article
- Searching for Metabolic Markers of Stroke in Human Plasma via NMR Analysis.International journal of molecular sciences · 2023Article
- Gas Chromatography-Mass Spectrometry-Based Cerebrospinal Fluid Metabolomics to Reveal the Protection of Coptisine against Transient Focal Cerebral Ischemia-Reperfusion Injury via Anti-Inflammation and Antioxidant.Molecules (Basel, Switzerland) · 2023Article
- L-proline transporter inhibitor (LQFM215) promotes neuroprotection in ischemic stroke.Pharmacological reports : PR · 2023Article
- Brain and serum metabolomic studies reveal therapeutic effects of san hua decoction in rats with ischemic stroke.Frontiers in endocrinology · 2023Article
- Untargeted metabonomic analysis of a cerebral stroke model in rats: a study based on UPLC-MS/MS.Frontiers in neuroscience · 2023Article
- Metabolomics of ischemic stroke: insights into risk prediction and mechanisms.Metabolic brain disease · 2022Review
- Serum and brain metabolomic study reveals the protective effects of Bai-Mi-Decoction on rats with ischemic stroke.Frontiers in pharmacology · 2022Article
- An Integrated Metabolomic Screening Platform Discovers the Potential Biomarkers of Ischemic Stroke and Reveals the Protective Effect and Mechanism of Folic Acid.Frontiers in molecular biosciences · 2022Article
- Screening of Phospholipids in Plasma of Large-Artery Atherosclerotic and Cardioembolic Stroke Patients With Hydrophilic Interaction Chromatography-Mass Spectrometry.Frontiers in molecular biosciences · 2022Article
- Neurovascular Unit as a Source of Ischemic Stroke Biomarkers-Limitations of Experimental Studies and Perspectives for Clinical Application.Translational stroke research · 2020Review
- [Plasma metabolomics combined with machine learning for classifying ischemic stroke subtypes and predicting the etiology of cryptogenic stroke].Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ischemic stroke is a neurovascular disorder caused by reduced or blockage of blood flow to the brain, which may permanently affect motor and cognitive abilities. The diagnostic of stroke is performed using imaging technologies, clinical evaluation, and neuropsychological protocols, but no blood test is available yet. In this work, we analyzed amino acid concentrations in blood plasma from poststroke patients in order to identify differences that could characterize the stroke etiology. Plasma concentrations of sixteen amino acids from patients with chronic ischemic stroke (n = 73) and the control group (n = 16) were determined using gas chromatography coupled to mass spectrometry (GC-MS). The concentration data was processed by Partial Least Squares-Discriminant Analysis (PLS-DA) to classify patients with stroke and control. The amino acid analysis generated a first model able to discriminate ischemic stroke patients from control group. Proline was the most important amino acid for classification of the stroke samples in PLS-DA, followed by lysine, phenylalanine, leucine, and glycine, and while higher levels of methionine and alanine were mostly related to the control samples. The second model was able to discriminate the stroke subtypes like atherothrombotic etiology from cardioembolic and lacunar etiologies, with lysine, leucine, and cysteine plasmatic concentrations being the most important metabolites. Our results suggest an amino acid biosignature for patients with chronic stroke in plasma samples, which can be helpful in diagnosis, prognosis, and therapeutics of these patients.
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