ArticleBioMed research international2019
L-Carnitine Reduces Oxidative Stress and Promotes Cells Differentiation and Bone Matrix Proteins Expression in Human Osteoblast-Like Cells.
Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
- From Discovery to Delivery: A Rapid and Targeted Proteomics Workflow for Monitoring Chinese Hamster Ovary Biomanufacturing.Molecular & cellular proteomics : MCP · 2025Article
- Transcriptomic Profile of Human Osteoblast-like Cells Grown on Trabecular Titanium.International journal of molecular sciences · 2025Article
- Association of plasma carnitine levels with bone mineral density and recent osteoporotic fracture.Frontiers in nutrition · 2025Article
- New insight into primary hyperparathyroidism using untargeted metabolomics.Scientific reports · 2024Article
- The Antioxidant Potential of Vitamins and Their Implication in Metabolic Abnormalities.Nutrients · 2024Review
- Prospective and challenges of locally applied repurposed pharmaceuticals for periodontal tissue regeneration.Frontiers in bioengineering and biotechnology · 2024Review
- Estimation of L-carnitine levels in diabetic completely edentulous patients for implant diagnosis: A cross-sectional study.Dental research journal · 2023Article
- Severe Obstructive Sleep Apnea Disrupts Vigilance-State-Dependent Metabolism.International journal of molecular sciences · 2022Article
- The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals.Biomolecules · 2022Review
- OSGIN2 regulates osteogenesis of jawbone BMSCs in osteoporotic rats.BMC molecular and cell biology · 2022Article
- In vitro maturation medium supplementation: utilization of repaglinide, L-carnitine, and mesenchymal stem cell-conditioned medium to improve developmental competence of oocytes derived from endometriosis mouse models.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2022Article
- The effect of combined oral contraceptives containing drospirenone and ethinylestradiol on serum levels of amino acids and acylcarnitines.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Dietary Application of Tannins as a Potential Mitigation Strategy for Current Challenges in Poultry Production: A Review.Animals : an open access journal from MDPI · 2020Review
- Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.International journal of molecular sciences · 2020Review
- Reactive oxygen species (ROS) generation as an underlying mechanism of inorganic phosphate (PFree radical biology & medicine · 2020Article
- The Nutraceutical Value of Carnitine and Its Use in Dietary Supplements.Molecules (Basel, Switzerland) · 2020Review
- L-Carnitine counteracts in vitro fructose-induced hepatic steatosis through targeting oxidative stress markers.Journal of endocrinological investigation · 2020Article
- Synergistic Utilization of Necrostatin-1 and Z-VAD-FMK Efficiently Promotes the Survival of Compression-Induced Nucleus Pulposus Cells via Alleviating Mitochondrial Dysfunction.BioMed research international · 2020Article
- Antioxidant Fucoidans Obtained from Tropical Seaweed Protect Pre-Osteoblastic Cells from Hydrogen Peroxide-Induced Damage.Marine drugs · 2019Article
- Metabolomics in Endocrinology: The Way Forward.Indian journal of endocrinology and metabolismReview
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone fragility and associated fracture risk are major problems in aging. Oxidative stress and mitochondrial dysfunction play a key role in the development of bone fragility. Mitochondrial dysfunction is closely associated with excessive production of reactive oxygen species (ROS). L-Carnitine (L-C), a fundamental cofactor in lipid metabolism, has an important antioxidant property. Several studies have shown how L-C enhances osteoblastic proliferation and activity. In the current study, we investigated the potential effects of L-C on mitochondrial activity, ROS production, and gene expression involved in osteoblastic differentiation using osteoblast-like cells (hOBs) derived from elderly patients. The effect of 5mM L-C treatment on mitochondrial activity and L-C antioxidant activity was studied by ROS production evaluation and cell-based antioxidant activity assay. The possible effects of L-C on hOBs differentiation were assessed by analyzing gene and protein expression by Real Time PCR and western blotting, respectively. L-C enhanced mitochondrial activity and improved antioxidant defense of hOBs. Furthermore, L-C increased the phosphorylation of Ca
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