Evidence map›Paper›PMID 30800516›Full record

ArticleBiomedical optics express2019

Investigation of random lasing as a feedback mechanism for tissue differentiation during laser surgery.

Martin Hohmann, Dominique Dörner, Fanuel Mehari, Chen Chen, Moritz Späth, Sebastian Müller, Heinz Albrecht, Florian Klämpfl, Michael Schmidt

Abstract read
In one paragraph

Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Biophotonic probes for bio-detection and imaging.Light, science & applications · 2021
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Martin HohmannFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Dominique DörnerFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Fanuel MehariFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Chen ChenFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Moritz SpäthFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Sebastian MüllerFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Heinz AlbrechtKliniken des Landkreises Neumarkt i.d.OPf., Department of Internal Medicine II, Nürnberger Str. 12, 92318 Neumarkt, Germany.
Florian KlämpflFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.
Michael SchmidtFriedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Institute of Photonic Technologies (LPT), Konrad-Zuse-Straßse 3/5, 91052 Erlangen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Laser surgery provides clean, fast and accurate cutting of tissue. However, it is difficult to detect what kind of tissue is being cut. Therefore, a wrong cut may lead to iatrogenic damage of structures. A feedback system should automatically stop the cutting process when a nerve is reached or accidentally being cut to prevent its damage. This could increase the applicability and safety of using a laser scalpel in surgical procedures. In this study, random lasing (RL) is used to differentiate between skin, fat, muscle and nerve tissue. Among these tissue types, a special emphasis is made on the differentiation of nerve from the rest of the tissues, especially fat since nerve is covered by a fatty layer. The differentiation is done for ex-vivo tissues of a pig animal model. The results show that random lasing can be used to differentiate these tissue types also under room light conditions in open air.

Identifiers

PMID30800516
PMCPMC6377870

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.