ArticleBiomedical optics express2019
Aperture phase modulation with adaptive optics: a novel approach for speckle reduction and structure extraction in optical coherence tomography.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Refractive adaptive optics scanning light ophthalmoscope with fast 2D MEMS scanner.Biomedical optics express · 2026Article
- Visible-Light Optical Coherence Tomography Fibergraphy of the Tree Shrew Retinal Ganglion Cell Axon Bundles.IEEE transactions on medical imaging · 2024Article
- Revealing speckle obscured living human retinal cells with artificial intelligence assisted adaptive optics optical coherence tomography.Communications medicine · 2024Article
- Adaptive optics scanning laser ophthalmoscopy and optical coherence tomography (AO-SLO-OCT) system forBiomedical optics express · 2023Article
- Spatio-temporal optical coherence tomography provides full thickness imaging of the chorioretinal complex.iScience · 2022Article
- Non-Local Mean Denoising Algorithm Based on Fractional Compact Finite Difference Scheme Effectively Reduces Speckle Noise in Optical Coherence Tomography Images.Micromachines · 2022Article
- Corneal imaging with blue-light optical coherence microscopy.Biomedical optics express · 2022Article
- UnifiedAdvances in optics and photonics · 2021Article
- Measurement of Diurnal Variation in Rod Outer Segment Length In Vivo in Mice With the OCT Optoretinogram.Investigative ophthalmology & visual science · 2020Article
- Angular compounding for speckle reduction in optical coherence tomography using geometric image registration algorithm and digital focusing.Scientific reports · 2020Article
- Crosstalk-free volumetricBiomedical optics express · 2019Article
- Temporal speckle-averaging of optical coherence tomography volumes forNeurophotonics · 2019Article
- Embedded deep learning in ophthalmology: making ophthalmic imaging smarter.Therapeutic advances in ophthalmologyReview
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Authors and funding
8 authors.
Funding
Abstract
Speckle is an inevitable consequence of the use of coherent light in imaging and acts as noise that corrupts image formation in most applications. Optical coherence tomographic imaging, as a technique employing coherence time gating, suffers from speckle. We present here a novel method of suppressing speckle noise intrinsically compatible with adaptive optics (AO) for confocal coherent imaging: modulation of the phase in the system pupil aperture with a segmented deformable mirror (DM) to introduce minor perturbations in the point spread function. This approach creates uncorrelated speckle patterns in a series of images, enabling averaging to suppress speckle noise while maintaining structural detail. A method is presented that efficiently determines the optimal range of modulation of DM segments relative to their AO-optimized position so that speckle noise is reduced while image resolution and signal strength are preserved. The method is active and independent of sample properties. Its effectiveness and efficiency are quantified and demonstrated by both
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Registered trials
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