ArticleBiomedical optics express2019
Multimodal imaging platform for optical virtual skin biopsy enabled by a fiber-based two-color ultrafast laser source.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Femtosecond pulse amplification on a chip.Nature communications · 2024Article
- Two-Photon Imaging for Non-Invasive Corneal Examination.Sensors (Basel, Switzerland) · 2022Review
- Deep-skin multiphoton microscopy of lymphatic vessels excited at the 1700-nm window in vivo.Biomedical optics express · 2021Article
- Single-laser-based simultaneous four-wavelength excitation source for femtosecond two-photon fluorescence microscopy.Biomedical optics express · 2021Article
- Low noise, self-phase-modulation-enabled femtosecond fiber sources tunable in 740-1236 nm for wide two-photon fluorescence microscopy applications.Biomedical optics express · 2021Article
- Protein-crystal detection with a compact multimodal multiphoton microscope.Communications biology · 2020Article
- Dense-UNet: a novel multiphotonQuantitative imaging in medicine and surgery · 2020Article
- Ultrafast Fiber Lasers: An Expanding Versatile Toolbox.iScience · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We demonstrate multimodal label-free nonlinear optical microscopy in human skin enabled by a fiber-based two-color ultrafast source. Energetic femtosecond pulses at 775 nm and 1250 nm are simultaneously generated by an Er-fiber laser source employing frequency doubling and self-phase modulation enabled spectral selection. The integrated nonlinear optical microscope driven by such a two-color femtosecond source enables the excitation of endogenous two-photon excitation fluorescence, second-harmonic generation, and third-harmonic generation in human skin. Such a 3-channel imaging platform constitutes a powerful tool for clinical application and optical virtual skin biopsy.
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Registered trials
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