Evidence map›Paper›PMID 30800422›Full record

ArticleJournal of virus eradication2019

Comparable carotid intima-media thickness among long-term virologically suppressed individuals with HIV and those without HIV in Thailand.

Opass Putcharoen, Suwapan Pleumkanitkul, Aurauma Chutinet, Pongpat Vongsayan, Jitrada Samajarn, Jiratchaya Sophonphan, Stephen J Kerr, Akarin Hiransuthikul, Sarawut Siwamogsatham, Kiat Ruxrungtham and 1 more

Abstract readEditorial
In one paragraph

Article in Journal of virus eradication, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Opass PutcharoenDivision of Infectious Diseases, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
Suwapan PleumkanitkulDivision of Infectious Diseases, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
Aurauma ChutinetDivision of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
Pongpat VongsayanDivision of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jitrada SamajarnDivision of Neurology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
Jiratchaya SophonphanHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Stephen J KerrHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Akarin HiransuthikulHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Sarawut SiwamogsathamDivision of Ambulatory and Hospital Medicine, Department of Medicine, Chulalongkorn University, Bangkok, Thailand.
Kiat RuxrungthamHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.
Anchalee AvihingsanonHIV Netherlands Australia Thailand Research Collaboration (HIV-NAT), Thai Red Cross AIDS Research Centre, Bangkok, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThis study compared the carotid intima-media thickness (cIMT) among well suppressed adult participants living with HIV and adults without HIV, aged >45 years.

methodsA cross-sectional, age and sex-matched study was conducted at two sites in Thailand: King Chulalongkorn Memorial Hospital (KCMH) and HIV-NAT. All participants had no evidence of coronary artery disease (CAD). Ultrasonography of the carotid artery was measured by one well-trained neurologist who was blinded to the participants' care. The primary endpoint was the difference in cIMT between participants with HIV and controls without HIV. Prevalence and predictive risk of cIMT≥0.9 mm were determined.

resultsOf 90 individuals, 60 were living with HIV. The overall median (IQR) age was 54.1 (52-60) years and 53.3% were male. For the group with HIV, the median duration of ART was 15 years and 33% were on boosted PIs. Compared to controls without HIV, the group with HIV had a higher proportion of hypertriglyceridaemia (48.3%

conclusionsWell-controlled and long-term treated participants living with HIV had comparable cIMT to Thai adults without HIV. Monitoring for progression of cIMT, carotid plaques and cardiovascular disease in this population is warranted to guide continued management.

Indexed as

antiretroviral therapycIMTcontrols without HIVparticipants living with HIVThailand

Identifiers

PMID30800422
PMCPMC6362911

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.