Evidence map›Paper›PMID 30800394›Full record

ArticleRoyal Society open science2019

Environmental fitness heterogeneity in the Moran process.

Kamran Kaveh, Alex McAvoy, Martin A Nowak

Abstract read
In one paragraph

Article in Royal Society open science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Fixation times on directed graphs.PLoS computational biology · 2024
    Article
  5. Review
  6. Article
  7. The Moran process on 2-chromatic graphs.PLoS computational biology · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kamran KavehHarvard University, Program for Evolutionary Dynamics, Cambridge, MA, USA.ORCID 0000-0002-8213-1797
Alex McAvoyHarvard University, Program for Evolutionary Dynamics, Cambridge, MA, USA.ORCID 0000-0002-9110-4635
Martin A NowakHarvard University, Program for Evolutionary Dynamics, Cambridge, MA, USA.ORCID 0000-0001-5489-0908

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many mathematical models of evolution assume that all individuals experience the same environment. Here, we study the Moran process in heterogeneous environments. The population is of finite size with two competing types, which are exposed to a fixed number of environmental conditions. Reproductive rate is determined by both the type and the environment. We first calculate the condition for selection to favour the mutant relative to the resident wild-type. In large populations, the mutant is favoured if and only if the mutant's spatial average reproductive rate exceeds that of the resident. But environmental heterogeneity elucidates an interesting asymmetry between the mutant and the resident. Specifically, mutant heterogeneity suppresses its fixation probability; if this heterogeneity is strong enough, it can even completely offset the effects of selection (including in large populations). By contrast, resident heterogeneity has no effect on a mutant's fixation probability in large populations and can amplify it in small populations.

Indexed as

environmental heterogeneityevolutionary dynamicsMoran process

Identifiers

PMID30800394
PMCPMC6366185

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.