Evidence map›Paper›PMID 30800328›Full record

ArticleOxford medical case reports2019

Symptomatic cerebrospinal fluid HIV-1 escape in two patients on second-line antiretroviral therapy in Uganda.

Kenneth Ssebambulidde, Ivan Segawa, Eva Laker, Mohammed Lamorde, Barbara Castelnouvo, Noeline Nakasujja, Andrea Calcagno

Erratum issuedAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxford medical case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Kenneth SsebambuliddeInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.ORCID 0000-0002-8125-0698
Ivan SegawaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Eva LakerInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Mohammed LamordeInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Barbara CastelnouvoInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Noeline NakasujjaInfectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.
Andrea CalcagnoUnit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.ORCID 0000-0003-2534-8815

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two HIV-infected individuals on second-line atazanavir-based antiretroviral therapy presented with neuropsychiatric symptoms. Cerebrospinal fluid HIV RNA was higher than plasma HIV RNA and antiretroviral regimens' optimization led to prompt resolution of symptoms in one. Patients on second-line atazanavir-based antiretroviral therapy with documented previous treatment failure may be at risk of symptomatic cerebrospinal fluid escape.

Identifiers

PMID30800328
PMCPMC6380528

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.