ArticleInternational journal of endocrinology2019
Relation of Different Components of Climate with Human Pituitary-Thyroid Axis and FT3/FT4 Ratio: A Study on Euthyroid and SCH Subjects in Two Different Seasons.
Article in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-Analysis of Free Triiodothyronine (FT3) Levels in Humans Depending on Seasonal Air Temperature Changes: Is the Variation in FT3 Levels Related to Nonshivering Thermogenesis?International journal of molecular sciences · 2023Pooled it
- Associations of combined exposure to selected metal mixtures with thyroid hormones in children: a cross-sectional study in China.Frontiers in public health · 2025Article
- Prognostic significance of free triiodothyronine levels in alpine region patients undergoing drug-coated balloon therapy for coronary heart disease.Journal of cardiothoracic surgery · 2024Article
- Coldness or Darkness? Which Places Greater Stress on the Thyroid? Seasonal Changes in Thyroid-Stimulating Hormone and Thyroid Hormones.Journal of clinical medicine · 2024Article
- Effects of altitude on thyroid disorders according to Chinese three-rung, ladder-like topography: national cross-sectional study.BMC public health · 2024Article
- Assessment of Joint Impact of Iodine, Selenium, and Zinc Status on Women's Third-Trimester Plasma Thyroid Hormone Concentrations.The Journal of nutrition · 2022Article
- Seasonal Variation in Thyroid Function in Over 7,000 Healthy Subjects in an Iodine-sufficient Area and Literature Review.Journal of the Endocrine Society · 2022Article
- Environmental and social determinants of thyroid cancer: A spatial analysis based on the Geographical Detector.Frontiers in endocrinology · 2022Article
- Associations of exposure to cadmium, antimony, lead and their mixture with gestational thyroid homeostasis.Environmental pollution (Barking, Essex : 1987) · 2021Article
- Climate and air pollution exposure are associated with thyroid function parameters: a retrospective cross-sectional study.Journal of endocrinological investigation · 2021Article
- Within-Person Variation in Serum Thyrotropin Concentrations: Main Sources, Potential Underlying Biological Mechanisms, and Clinical Implications.Frontiers in endocrinology · 2021Review
- Seasonal Changes of Thyroid Function Parameters in Women of Reproductive Age Between 2012 and 2018: A Retrospective, Observational, Single-Center Study.Frontiers in endocrinology · 2021Observational
- Association of Exposure to Ambient Air Pollution With Thyroid Function During Pregnancy.JAMA network open · 2019Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVarious changes in thyroid hormones (TH) and thyroid-stimulating hormone (TSH) level were observed in different seasons among euthyroid and hypothyroid subjects living in areas with an extreme temperature difference between summer and winter.
objectivesThis study aims at finding the effect of temperate climate on the seasonal variations of TSH and TH in euthyroid and subclinical hypothyroidism (SCH) subjects and at evaluating if the test season has an effect on the number of subjects diagnosed as SCH. It basically focuses on the relation of different components of climate with TH and TSH.
methodIn a prospective study on 152 healthy (euthyroid) volunteers and 25 SCH subjects, the serum hormone levels (TSH, FT4, and FT3) were measured in both the summer and winter seasons and correlated with all the climate components using Pearson's correlation coefficient. The effect of duration of outdoor exposure on hormone levels was compared using a paired sample
resultsSmall but statistically significant increased FT3 level and decreased FT4 level were observed during the winter season in euthyroid and SCH subjects, respectively. There was a significant negative correlation between FT3 and FT3/FT4 ratio with temperature and sunshine duration and a positive correlation with humidity and atmospheric pressure. A positive correlation was found between FT4 and sunshine duration.
conclusionThe climate components contributed to the slight variance in hormone levels in different seasons, and the effect was mostly on peripheral conversion of FT4 to FT3 rather than the pituitary-thyroid axis leading to slightly higher FT3 in winter. Seasonal variation does not affect the diagnosis of SCH cases.
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