ArticleJournal of geriatric cardiology : JGC2019
Diagnosing heart failure in centenarians.
Article in Journal of geriatric cardiology : JGC, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Echocardiographic Assessment of Cardiac Structure and Function of Centenarians: A Systematic Review.Geriatrics (Basel, Switzerland) · 2025Review
- Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.Scientific reports · 2024Article
- Polygenic prediction of human longevity on the supposition of pervasive pleiotropy.medRxiv : the preprint server for health sciences · 2023Article
- Improved cardiovascular profile in Danish centenarians? A comparative study of two birth cohorts born 20 years apart.European geriatric medicine · 2022Article
- Fixed Ratio versus Lower Limit of Normality for Diagnosing COPD in Primary Care: Long-Term Follow-Up of EGARPOC Study.International journal of chronic obstructive pulmonary disease · 2020Article
- Health of Spanish centenarians: a cross-sectional study based on electronic health records.BMC geriatrics · 2019Observational
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAs a consequence of the demographic development with increasing proportion of older people, the prevalence of heart failure (HF) is expected to rise with considerable economic and societal costs. However, knowledge on cardiac structure and function among population-based samples of the exceptional old is lacking.
methodsPopulation-based study of all persons (no exclusion criteria) living in the western part of Denmark and turning 100 years in the year 2015. In-home face-to-face interviews were conducted, and echocardiography and blood sampling for plasma Brain Natriuretic Peptide (BNP) were offered to those who were able to give consent.
resultsOut of 303 eligible, 238 (79%) participated, of which 125 (53%) accepted echocardiography. Left ventricular (LV) dysfunction was present in 68 (54%) of the participants of whom less than half had HF symptoms. Pulmonary hypertension was present in 31 (42%) with no correlation to LV function. The well-known association between increased level of BNP and the prevalence of LV dysfunction could not be confirmed.
conclusionsThis in-home echocardiographic study shows that more than half of the participants had LV dysfunction, although mostly asymptomatic. There was no association between heart failure symptoms and LV dysfunction. Furthermore, BNP seems to have lost its biomarker potential to rule out heart failure in centenarians. Due to the latter, and the questionable symptom validity among centenarians, the current criteria to diagnose HF might be less valid in a centenarian population than in younger olds.
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Registered trials
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