Evidence map›Paper›PMID 30800122›Full record

ArticleFrontiers in immunology2019

Compartmentalization of Immune Response and Microbial Translocation in Decompensated Cirrhosis.

Camila Alvarez-Silva, Robert Schierwagen, Alessandra Pohlmann, Fernando Magdaleno, Frank E Uschner, Patrick Ryan, Maria J G T Vehreschild, Joan Claria, Eicke Latz, Benjamin Lelouvier and 2 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06523608 (Prediction of Decompensation and HCC Development in Patients With Advanced Chronic Liver Disease by the PLEASE and M10S20 Algorithms), which is not on this map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06523608 recruitingnot on this mapstarted 2024, after this paper: background citation

Prediction of Decompensation and HCC Development in Patients With Advanced Chronic Liver Disease by the PLEASE and M10S20 Algorithms

Typeobservational_patient_registrySponsorUniversity Hospital MuensterRan2024 to 2027Enrolled600ConditionsLiver Diseases, Hepatocellular Carcinoma, Hepatocarcinoma, Advanced Chronic Liver DiseaseArmsStandard survillance protocol, Stratified survillance protocol
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Interaction of inflammation and portal hypertension in cirrhosis progression.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  5. Article
  6. Acute and non-acute decompensation of liver cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Cirrhosis-associated immune dysfunction.Nature reviews. Gastroenterology & hepatology · 2022
    Review
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 5 countries.

Camila Alvarez-SilvaNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Robert SchierwagenDepartment of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany.
Alessandra PohlmannDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Fernando MagdalenoDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Frank E UschnerDepartment of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany.
Patrick RyanDepartment of Internal Medicine I, University of Bonn, Bonn, Germany.
Maria J G T VehreschildMedical Clinic II, University Center for Infectious Diseases, University Hospital Frankfurt, Frankfurt, Germany.
Joan ClariaEuropean Foundation for the Study of Chronic Liver Failure, Barcelona, Spain.
Eicke LatzInstitute of Innate Immunity, University of Bonn, Bonn, Germany.
Benjamin LelouvierVaiomer, Labège, France.
Manimozhiyan ArumugamNovo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jonel TrebickaDepartment of Internal Medicine I, Goethe University Clinic Frankfurt, Frankfurt, Germany.
University of Bonn · DEEuropean Foundation for the Study of Chronic Liver Failure · ESUniversity of Copenhagen · DKUniversity Hospital Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdultAgedAged, 80 and overBacterial InfectionsBiomarkersDNA, BacterialFemaleFibrosisHumansInflammationInterleukin-6Interleukin-8Liver CirrhosisMaleMicrobiotaMiddle AgedBiomarkersDNA, BacterialInterleukin-6Interleukin-8RNA, Ribosomal, 16Sacute-on-chronic liver failureascitescirrhosiscytokinesmicrobiomemyeloid cellssystemic inflammation

Identifiers

PMID30800122
PMCPMC6376951
OpenAlexW2914645682

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.