Evidence map›Paper›PMID 30800121›Full record

Trial reportFrontiers in immunology2019

Impact of Vitamin D Supplementation on Influenza Vaccine Response and Immune Functions in Deficient Elderly Persons: A Randomized Placebo-Controlled Trial.

Nicolas Goncalves-Mendes, Jérémie Talvas, Christian Dualé, Aline Guttmann, Violaine Corbin, Geoffroy Marceau, Vincent Sapin, Patrick Brachet, Bertrand Evrard, Henri Laurichesse and 1 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01893385 (Impact of Vitamin D Supplementation on Immune Functions), which is not on this map. Cited by 78 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 6 pooled it
16.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01893385 phase2terminatednot on this map

Impact of Vitamin D Supplementation on Immune Functions: Study in Subjects Aged Over 65 Years Vaccinated Against Influenza

TypeinterventionalSponsorUniversity Hospital, Clermont-FerrandRan2013 to 2014Enrolled37ConditionsD Vitamin Deficiency PatientsArmsVitamin D (drug)
3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 6 syntheses or guidelines pooled it, 144 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Guideline
  6. Pooled it
  7. Trial
  8. Trial
  9. Treatment With 25-Hydroxyvitamin DEndocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2021
    Trial
  10. Trial
  11. Review
  12. Article
  13. Functional Food Ingredients Enhancing Immune Health.International journal of molecular sciences · 2025
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. How does geographical diversity shape vaccine efficacy?Clinical and experimental vaccine research · 2024
    Review

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Nicolas Goncalves-MendesUniversity of Clermont Auvergne, INRA, UMR 1019 Human Nutrition Unit, Clermont-Ferrand, France.
Jérémie TalvasUniversity of Clermont Auvergne, INRA, UMR 1019 Human Nutrition Unit, Clermont-Ferrand, France.
Christian DualéCHU Clermont-Ferrand, INSERM CIC 1405, University of Clermont Auvergne, Clermont-Ferrand, France.
Aline GuttmannCHU Clermont-Ferrand, Biostatistics Unit, University of Clermont Auvergne, Clermont-Ferrand, France.
Violaine CorbinCHU Clermont-Ferrand, Infectious Diseases Department, University of Clermont Auvergne, Clermont-Ferrand, France.
Geoffroy MarceauCHU Clermont-Ferrand, Biochemistry and Molecular Biology Department, University of Clermont Auvergne, Clermont-Ferrand, France.
Vincent SapinCHU Clermont-Ferrand, Biochemistry and Molecular Biology Department, University of Clermont Auvergne, Clermont-Ferrand, France.
Patrick BrachetUniversity of Clermont Auvergne, INRA, UMR 1019 Human Nutrition Unit, Clermont-Ferrand, France.
Bertrand EvrardUniversity of Clermont Auvergne, INRA, UMR 1019 Human Nutrition Unit, Clermont-Ferrand, France.
Henri LaurichesseUniversity of Clermont Auvergne, INRA, UMR 1019 Human Nutrition Unit, Clermont-Ferrand, France.
Marie-Paule VassonUniversity of Clermont Auvergne, INRA, UMR 1019 Human Nutrition Unit, Clermont-Ferrand, France.
University of Clermont Auvergne · FRCentre Hospitalier Universitaire de Clermont-Ferrand · FRUnité de Nutrition Humaine · FRCentre de Recherche en Nutrition Humaine d'Auvergne · FRInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AgedDietary SupplementsDouble-Blind MethodFemaleHumansImmune ToleranceInfluenza, HumanInfluenza VaccinesMaleOrthomyxoviridaePlacebo EffectTh1 CellsTh1-Th2 BalanceTh2 CellsTransforming Growth Factor betaVaccinationInfluenza VaccinesTransforming Growth Factor betaVitamin Dagingcathelicidincytokineinfluenza vaccinationleukocyte phenotypingrandomized trialvitamin-D deficiency

Identifiers

PMID30800121
PMCPMC6375825
OpenAlexW2911326189

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.